STUDIES ON CHEMOTHERAPY OF PARASITIC HELMINTHS (VIM). EFFECTS OF SOME POSSIBLE NEUROTRANSMITTERS ON THE MOTILITY OF ANGIOSTRONGYLUS CANTONENSIS

• Published in: Japanese journal of pharmacology 1982-01, Vol.32 (4), p.643-654
• Main Authors: TERADA, Mamoru, ISHII, Akira I., KINO, Hideto, SANO, Motohito
• Format: Article
• Language: English
• Subjects: Angiostrongylus - drug effects; Angiostrongylus - physiology; Angiostrongylus cantonensis; Animals; Female; GABA Antagonists; gamma-Aminobutyric Acid - pharmacology; Locomotion and motility; Metastrongyloidea - physiology; Movement - drug effects; Nervous system, Nematoda; Neurotransmitter Agents - pharmacology; Papaverine - pharmacology; Parastrongylus cantonensis; pharmacology; Rats; Serotonin - pharmacology; Serotonin Antagonists - pharmacology; Sympatholytics - pharmacology; Sympathomimetics - pharmacology
• ISSN: 0021-5198; 1347-3506
• DOI: 10.1016/S0021-5198(19)52642-7

Effects of some possible neurotransmitters such as GABA, adrenergic drugs, and 5-HT and their antagonists on the motility of Angio-strongylus cantonensis were studied. Paralysis was caused by GABA, avermectin Bia (Av-Bia), piperazine and α-adrenergic agonists such as adrenaline, noradrenaline, phenylephrine, Clonidine and methoxamine, but not by β-adrenergic agonists such as isoproterenol. The paralysis by GABA or Av-Bia was antagonized by GABA antagonists such as Picrotoxin and/or bicuculline with cholinergic agents such as N-methylcytisine (N-MC) or eserine. The paralysis elicited by α-adrenergic agonists was antagonized by α-adrenergic antagonists such as phentolamine and dibenamine, but not by β-adrenergic antagonists such as propranolol. 5-HT affected the motility of A cantonensis paralytically or spastically. The paralysis induced by 5-HT was antagonized by α-adrenergic antagonists such as phentolamine and dibenamine, while the contraction induced by this compound was further stimulated by N-MC. but antagonized by strychnine. Other agents such as glutamine, glycine, aspartic acid, taurine, and substance P showed little effect on the motility of A. cantonensis. From these findings on the neuropharmacological properties of A. cantonensis. it is suggested that this worm is useful as an excellent nematodal model for the investigation of anthelminthics. In addition, this worm may also useful as one of screening models of drugs affecting the central nervous system in mammals.