Transmural triglycerides in acute myocardial ischaemia

The effect of coronary artery occlusion on endogenous triglycerides of left ventricular subepicardium and subendocardium was studied in the open-chest anaesthetised dog. Under control conditions, the subepicardium was found to have a greater concentration of triglycerides than the subendocardium. Th...

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Bibliographic Details
Published in:Cardiovascular research 1978-11, Vol.12 (11), p.659-665
Main Authors: JESMOK, GARY J., WARLTIER, DAVID C., GROSS, GARRETT J., HARDMAN, HAROLD F.
Format: Article
Language:English
Subjects:
Animals
Coronary Disease - metabolism
Dogs
Female
Heart - drug effects
Heart Ventricles - drug effects
Heart Ventricles - metabolism
Male
Myocardium - metabolism
Propranolol - pharmacology
Triglycerides - metabolism
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Summary:The effect of coronary artery occlusion on endogenous triglycerides of left ventricular subepicardium and subendocardium was studied in the open-chest anaesthetised dog. Under control conditions, the subepicardium was found to have a greater concentration of triglycerides than the subendocardium. Thirty minutes after acute coronary artery occlusion there was a decrease followed by a steady increase at 60, 120, and 240 min in subepicardial triglycerides of the ischaemic region. No change in triglycerides in the subendocardium of normal or ischaemic regions was observed. The initial decrease of subepicardial triglycerides in the ischaemic region was blocked by administration of propranolol or bevantolol (CI-775; a specific β1 antagonist) given 30 min before occlusion. It is concluded that the effect of coronary artery ligation on transmural endogenous triglycerides is biphasic with an initial period of increased mobilisation followed by a period of increased deposition.
ISSN:0008-6363
1755-3245
DOI:10.1093/cvr/12.11.659