Different cell clones in bone marrow and spleen of a patient with chronic myelocytic leukemia (CML) in blastic phase

The chromosome study of a patient with chronic myelocytic leukemia in blastic phase revealed a 46,XY,Ph1/47,XY,Ph1,+8 cytogenetic constitution in bone marrow cells and a 46,XY,Ph1/48,XY,2Ph1, + 19 cytogenetic constitution in spleen cells. As the cell clones exhibiting chromosome abnormalities in add...

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Bibliographic Details
Published in:Cancer 1978-12, Vol.42 (6), p.2707-2709
Main Authors: Olinici, C. D., Petrov, L., Macavei, I., Dobay, Olga
Format: Article
Language:English
Subjects:
Adult
Bone Marrow - pathology
Chromosome Aberrations
Chromosomes, Human, 19-20
Chromosomes, Human, 21-22 and Y
Chromosomes, Human, 6-12 and X
Clone Cells - pathology
Humans
Leukemia, Myeloid - genetics
Leukemia, Myeloid - pathology
Male
Spleen - pathology
Trisomy
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Summary:The chromosome study of a patient with chronic myelocytic leukemia in blastic phase revealed a 46,XY,Ph1/47,XY,Ph1,+8 cytogenetic constitution in bone marrow cells and a 46,XY,Ph1/48,XY,2Ph1, + 19 cytogenetic constitution in spleen cells. As the cell clones exhibiting chromosome abnormalities in addition to the Ph1 chromosome evolved apparently independently, it is suggested that the acute transformation had a bifocal, myeloid and splenic origin. Cancer 42:2707–2709, 1978.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(197812)42:6<2707::AID-CNCR2820420627>3.0.CO;2-5