Spontaneous diabetes in BB rats: evidence for a T cell dependent immune response defect

Approximately 50% of BB rats develop insulinopenic hyperglycaemia and ketosis spontaneously in association with insulitis. Amelioration of the syndrome by immunosuppression suggests a cell mediated immune pathogenesis. Analysis of the cell-mediated immune profile of overtly diabetic and normoglycaem...

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Bibliographic Details
Published in:Diabetologia 1982-10, Vol.23 (4), p.359-364
Main Authors: Bellgrau, D, Naji, A, Silvers, W K, Markmann, J F, Barker, C F
Format: Article
Language:English
Subjects:
Animals
Concanavalin A
Diabetes Mellitus, Experimental - immunology
Interleukin-2
Leukocyte Count
Lymphocyte Activation
Lymphocyte Culture Test, Mixed
Lymphocytes
Rats
T-Lymphocytes - immunology
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Summary:Approximately 50% of BB rats develop insulinopenic hyperglycaemia and ketosis spontaneously in association with insulitis. Amelioration of the syndrome by immunosuppression suggests a cell mediated immune pathogenesis. Analysis of the cell-mediated immune profile of overtly diabetic and normoglycaemic diabetes prone BB rats indicates that they are lymphocytopenic relative to non-diabetes prone BB rats and that the T cell pool is particularly affected. Furthermore, lymphocytes from diabetic and diabetes prone BB rats, while producing normal responses to the T cell mitogen concanavalin A, do not respond when mixed in vitro with major histocompatibility complex incompatible lymphocytes. This anergy is not restored either by enriching the responding cell population for T cells or by adding exogenous T cell growth promoting factor. Thus BB rats have a numerical and regulatory deficit of their T cells which could be related to their propensity for diabetes.
ISSN:0012-186X
1432-0428
DOI:10.1007/BF00253745