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Spontaneous diabetes in BB rats: evidence for a T cell dependent immune response defect

Approximately 50% of BB rats develop insulinopenic hyperglycaemia and ketosis spontaneously in association with insulitis. Amelioration of the syndrome by immunosuppression suggests a cell mediated immune pathogenesis. Analysis of the cell-mediated immune profile of overtly diabetic and normoglycaem...

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Published in:	Diabetologia 1982-10, Vol.23 (4), p.359-364
Main Authors:	Bellgrau, D, Naji, A, Silvers, W K, Markmann, J F, Barker, C F
Format:	Article
Language:	English
Subjects:	Animals Concanavalin A Diabetes Mellitus, Experimental - immunology Interleukin-2 Leukocyte Count Lymphocyte Activation Lymphocyte Culture Test, Mixed Lymphocytes Rats T-Lymphocytes - immunology
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container_issue	4
container_start_page	359
container_title	Diabetologia
container_volume	23
creator	Bellgrau, D Naji, A Silvers, W K Markmann, J F Barker, C F
description	Approximately 50% of BB rats develop insulinopenic hyperglycaemia and ketosis spontaneously in association with insulitis. Amelioration of the syndrome by immunosuppression suggests a cell mediated immune pathogenesis. Analysis of the cell-mediated immune profile of overtly diabetic and normoglycaemic diabetes prone BB rats indicates that they are lymphocytopenic relative to non-diabetes prone BB rats and that the T cell pool is particularly affected. Furthermore, lymphocytes from diabetic and diabetes prone BB rats, while producing normal responses to the T cell mitogen concanavalin A, do not respond when mixed in vitro with major histocompatibility complex incompatible lymphocytes. This anergy is not restored either by enriching the responding cell population for T cells or by adding exogenous T cell growth promoting factor. Thus BB rats have a numerical and regulatory deficit of their T cells which could be related to their propensity for diabetes.
doi_str_mv	10.1007/BF00253745
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Amelioration of the syndrome by immunosuppression suggests a cell mediated immune pathogenesis. Analysis of the cell-mediated immune profile of overtly diabetic and normoglycaemic diabetes prone BB rats indicates that they are lymphocytopenic relative to non-diabetes prone BB rats and that the T cell pool is particularly affected. Furthermore, lymphocytes from diabetic and diabetes prone BB rats, while producing normal responses to the T cell mitogen concanavalin A, do not respond when mixed in vitro with major histocompatibility complex incompatible lymphocytes. This anergy is not restored either by enriching the responding cell population for T cells or by adding exogenous T cell growth promoting factor. 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subjects	Animals Concanavalin A Diabetes Mellitus, Experimental - immunology Interleukin-2 Leukocyte Count Lymphocyte Activation Lymphocyte Culture Test, Mixed Lymphocytes Rats T-Lymphocytes - immunology
title	Spontaneous diabetes in BB rats: evidence for a T cell dependent immune response defect
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