Pituitary function before and after transsphenoidal adenomectomy in patients with Cushing's disease

Over the past 4 years 11 patients with Cushing's disease have been operated on by a transsphenoidal microsurgical technique. All patients had small intrahypophyseal adenomas found at operation. Eight of the 11 patients had a remission of the disease on the basis of clinical evaluation and hormo...

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Bibliographic Details
Published in:Acta neurochirurgica 1982-03, Vol.65 (1-2), p.29-40
Main Authors: Ambrosi, B, Giovanelli, M, Gaini, S M, Bochicchio, D, Riva, E, Tomei, G, Zavanone, M, Faglia, G
Format: Article
Language:English
Subjects:
Adolescent
Adrenalectomy - methods
Adrenocorticotropic Hormone - blood
Adult
Cushing Syndrome - blood
Cushing Syndrome - physiopathology
Cushing Syndrome - surgery
Endocrine Glands - physiopathology
Female
Humans
Hydrocortisone - blood
Male
Middle Aged
Outcome and Process Assessment (Health Care)
Pituitary Gland - physiopathology
Postoperative Period
Sphenoid Sinus - surgery
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Summary:Over the past 4 years 11 patients with Cushing's disease have been operated on by a transsphenoidal microsurgical technique. All patients had small intrahypophyseal adenomas found at operation. Eight of the 11 patients had a remission of the disease on the basis of clinical evaluation and hormonal studies. The endocrinological results revealed a transient state of hypocorticism in all successfully treated patients. Within 6-8 months after operation recovery of hypothalamic-pituitary-adrenal function and other tropin function took place. These findings, together with the absence of recurrence up to now, further confirm the efficacy of transsphenoidal surgery in the management of patients with Cushing's disease.
ISSN:0001-6268
0942-0940
DOI:10.1007/BF01405439