CARDIOVASCULAR EFFECTS OF ALFENTANIL ANAESTHESIA

In 30 patients undergoing cardiac surgery, anaesthesia was induced with alfentaml 125 μg kg-1 and maintained with an infusion of alfentanil 0.5 mg kg-1 h-1 until the start of cardiopulmonary bypass, and alfentanil 0 25mg kg-1h-1 thereafter until the end of surgery. Pancuronium was given and the lung...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1982-11, Vol.54 (11), p.1185-1190
Main Authors: SEBEL, P.S., BOVILL, J.G., VAN DER HAVEN, A.
Format: Article
Language:English
Subjects:
Alfentanil
Analgesics, Opioid - pharmacology
Anesthesia, Intravenous
Cardiac Surgical Procedures
Cardiopulmonary Bypass
Female
Fentanyl - analogs & derivatives
Fentanyl - pharmacology
Hemodynamics - drug effects
Humans
Male
Middle Aged
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Summary:In 30 patients undergoing cardiac surgery, anaesthesia was induced with alfentaml 125 μg kg-1 and maintained with an infusion of alfentanil 0.5 mg kg-1 h-1 until the start of cardiopulmonary bypass, and alfentanil 0 25mg kg-1h-1 thereafter until the end of surgery. Pancuronium was given and the lungs ventilated with air in oxygen. In the majority of patients, there were no tignifiranr changes in cardiovascular measurements throughout the study, although two received sodium nitroprusside for the control of hypertension, and in one patient hypertension was so severe that the method of anaesthesia was abandoned. Transient hypotension occurred on induction in one patient. Twenty-six patients required alfentanil supplementation before bypass. These results indicate that anaesthesia with an alfentanil infusion provides satisfactory cardiovascular stability for cardiac surgery.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/54.11.1185