Biological rhythms: Circadian clocks limited by noise

Circadian rhythms, which provide internal daily periodicity, are used by a wide range of organisms to anticipate daily changes in the environment. It seems that these organisms generate circadian periodicity by similar biochemical networks within a single cell. A model based on the common features o...

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Bibliographic Details
Published in:Nature (London) 2000-01, Vol.403 (6767), p.267-268
Main Authors: Barkai, Naama, Leibler, Stanislas
Format: Article
Language:English
Subjects:
Biological rhythms
Circadian rhythm
Circadian rhythms
Environmental changes
Growth models
Insects
Organisms
Symmetry
Online Access:Get full text
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Summary:Circadian rhythms, which provide internal daily periodicity, are used by a wide range of organisms to anticipate daily changes in the environment. It seems that these organisms generate circadian periodicity by similar biochemical networks within a single cell. A model based on the common features of these biochemical networks shows that a circadian network can oscillate reliably in the presence of stochastic biochemical noise and when cellular conditions are altered. We propose that the ability to resist such perturbations imposes strict constraints on the oscillation mechanisms underlying circadian periodicity in vivo.
ISSN:0028-0836
1476-4687
DOI:10.1038/35002258