Blurring the Boundary: The Nuclear Envelope Extends Its Reach

The past decade has seen a complete rethinking of the traditional view of the nuclear envelope as simply a passive enclosure for the chromosomes. The convergence of several lines of clinical and basic research has revealed additional roles in both signaling and mitotic progression. It is becoming ap...

Full description

Saved in:
Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2007-11, Vol.318 (5855), p.1408-1412
Main Authors: Stewart, Colin L, Roux, Kyle J, Burke, Brian
Format: Article
Language:English
Subjects:
Animals
Cell division
Cellular biology
Chromatin
Chromosomes
Cytoplasm - physiology
Cytoplasm - ultrastructure
Cytoskeleton
Cytoskeleton - parasitology
Cytoskeleton - physiology
Cytoskeleton - ultrastructure
Genetic Diseases, Inborn - pathology
Genetic Diseases, Inborn - physiopathology
Genetic mutation
Humans
Lamins
Lamins - genetics
Mitosis
Mutation
Nuclear Envelope - physiology
Nuclear Envelope - ultrastructure
Nuclear lamina
Nuclear Lamina - physiology
Nuclear Lamina - ultrastructure
Nuclear membrane
Nuclear Pore - physiology
Nuclear Pore - ultrastructure
Proteins
Review
Signal Transduction
Somatic cells
Vertebrates
Virus Diseases - metabolism
Virus Diseases - virology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The past decade has seen a complete rethinking of the traditional view of the nuclear envelope as simply a passive enclosure for the chromosomes. The convergence of several lines of clinical and basic research has revealed additional roles in both signaling and mitotic progression. It is becoming apparent that the nuclear envelope defines not only nuclear organization but also that of the cytoskeleton and, in this way, integrates both nuclear and cytoplasmic architecture.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1142034