Bioreactor systems for the production of biopharmaceuticals from animal cells

The demand for biopharmaceutical products is set to see a significant increase over the next few years. As a consequence, the processes used to produce these products must be able to meet market requirements. The present paper reviews the current technologies available for animal cell culture and hi...

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Bibliographic Details
Published in:Biotechnology and applied biochemistry 2006-07, Vol.45 (1), p.1-12
Main Authors: Warnock, James N., Al-Rubeai, Mohamed
Format: Article
Language:English
Subjects:
animal cell biotechnology
Animals
Biological and medical sciences
biopharmaceuticals
bioreactor system
Bioreactors
Biotechnology
Biotechnology - instrumentation
Biotechnology - methods
Cell Culture Techniques - instrumentation
Cell Culture Techniques - methods
Cells, Immobilized
CHO Cells - metabolism
Cricetinae
Cricetulus
Dialysis - instrumentation
Dialysis - methods
Equipment Design - instrumentation
filtration system
Fundamental and applied biological sciences. Psychology
microcarrier
Perfusion - methods
perfusion culture
Recombinant Proteins - biosynthesis
Technology, Pharmaceutical - instrumentation
Technology, Pharmaceutical - methods
Vaccines - biosynthesis
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Summary:The demand for biopharmaceutical products is set to see a significant increase over the next few years. As a consequence, the processes used to produce these products must be able to meet market requirements. The present paper reviews the current technologies available for animal cell culture and highlights the advantages and disadvantages of each method, while also providing details of recent case studies. Processes are described for both suspension and anchorage‐dependent cell lines.
ISSN:0885-4513
1470-8744
DOI:10.1042/BA20050233