Suppression of postganglionic sympathetic discharges by pentobarbital in endotoxic cats

Pentobarbital (7–9 mg/kg) profoundly suppressed the sympathetic postganglionic cardiac and splenic discharges in endotoxic cats under chloralose anesthesia. Concurrently, the pre‐existent tachycardia was replaced by bradycardia, and the blood pressure fell further. The findings are interpreted to im...

Full description

Saved in:
Bibliographic Details
Published in:Acta physiologica Scandinavica 1982-02, Vol.114 (2), p.267-270
Main Authors: HALINEN, M. O., HAKUMÄKI, M. O. K., SARAJAS, H. S. S.
Format: Article
Language:English
Subjects:
Animals
Blood Pressure - drug effects
Cats
Efferent pathways
Efferent Pathways - drug effects
endotoxin intravenous injections
Endotoxins - pharmacology
Female
Heart - innervation
Heart Rate - drug effects
Male
pentobarbital
Pentobarbital - pharmacology
Spleen - innervation
sympathetic nervous system
Sympathetic Nervous System - drug effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Pentobarbital (7–9 mg/kg) profoundly suppressed the sympathetic postganglionic cardiac and splenic discharges in endotoxic cats under chloralose anesthesia. Concurrently, the pre‐existent tachycardia was replaced by bradycardia, and the blood pressure fell further. The findings are interpreted to imply a pentobarbital‐induced syrnpatolysis.
ISSN:0001-6772
1365-201X
DOI:10.1111/j.1748-1716.1982.tb06981.x