Biotransformation of zerumbone by Caragana chamlagu

Suspension cultured cells of Caragana chamlagu (Leguminosae) converted zerumbone (1) into zerumbone epoxide (2) as the intermediate, (2R,3R,7R)-2,3-epoxy-9-humulen-8-one (3) and (2R,3S,7R)-2,3-epoxy-9-humulen-8-one (4) as new sesquiterpenes in 11%, 36% and 21% yields, respectively.

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Bibliographic Details
Published in:Biotechnology letters 2008-11, Vol.30 (11), p.2025-2029
Main Authors: Sakamaki, Hiroshi, Itoh, Ken-ichi, Kitanaka, Susumu, Sawada, Seiji, Horiuchi, C. Akira
Format: Article
Language:English
Subjects:
Applied Microbiology
Biochemistry
Bioconversions. Hemisynthesis
Bioengineering
Biological and medical sciences
Biomedical and Life Sciences
Biotechnology
Biotransformation
Caragana
Caragana - cytology
Caragana - metabolism
Catalysts
Cellular biology
Fundamental and applied biological sciences. Psychology
Life Sciences
Mass Spectrometry
Methods. Procedures. Technologies
Microbiology
Molecular Structure
Original Research Paper
Sesquiterpenes - chemistry
Sesquiterpenes - metabolism
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Summary:Suspension cultured cells of Caragana chamlagu (Leguminosae) converted zerumbone (1) into zerumbone epoxide (2) as the intermediate, (2R,3R,7R)-2,3-epoxy-9-humulen-8-one (3) and (2R,3S,7R)-2,3-epoxy-9-humulen-8-one (4) as new sesquiterpenes in 11%, 36% and 21% yields, respectively.
ISSN:0141-5492
1573-6776
DOI:10.1007/s10529-008-9783-5