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CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones
OCCUPANCY of the T-cell antigen receptor is insufficient to induce T-cell activation optimally; a second co-stimulatory signal is required 1 . Exposure of T-cell clones to complexes of antigen with major histocompatibility complex molecules in the absence of the co-stimulatory signal induces a state...
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Published in: | Nature (London) 1992-04, Vol.356 (6370), p.607-609 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | OCCUPANCY of the T-cell antigen receptor is insufficient to induce T-cell activation optimally; a second co-stimulatory signal is required
1
. Exposure of T-cell clones to complexes of antigen with major histocompatibility complex molecules in the absence of the co-stimulatory signal induces a state of clonal anergy. This requirement for two stimuli for T-cell activation could have an important role
in vivo
in establishing peripheral tolerance to antigens not encountered in the thymus
1,2
. The receptor on T cells required for the co-stimulatory stimulus involved in the prevention of anergy has not been identified. The human T-cell antigen CD28 provides a signal that can synergize with T-cell antigen receptor stimulation in activating T cells to proliferate and secrete lymphokines
3–6
. Here we report that a monoclonal antibody against the murine homologue of CD28 (ref. 7; J.A.G.
et al
., manuscript in preparation) can provide a co-stimulatory signal to naive CD4
+
T cells and to T-cell clones. Moreover, we demonstrate that this co-stimulatory signal can block the induction of anergy in T-cell clones. |
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ISSN: | 0028-0836 1476-4687 |
DOI: | 10.1038/356607a0 |