Loading…

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

OCCUPANCY of the T-cell antigen receptor is insufficient to induce T-cell activation optimally; a second co-stimulatory signal is required 1 . Exposure of T-cell clones to complexes of antigen with major histocompatibility complex molecules in the absence of the co-stimulatory signal induces a state...

Full description

Saved in:
Bibliographic Details
Published in:Nature (London) 1992-04, Vol.356 (6370), p.607-609
Main Authors: Harding, Fiona A, McArthur, James G, Gross, Jane A, Raulet, David H, Allison, James P
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:OCCUPANCY of the T-cell antigen receptor is insufficient to induce T-cell activation optimally; a second co-stimulatory signal is required 1 . Exposure of T-cell clones to complexes of antigen with major histocompatibility complex molecules in the absence of the co-stimulatory signal induces a state of clonal anergy. This requirement for two stimuli for T-cell activation could have an important role in vivo in establishing peripheral tolerance to antigens not encountered in the thymus 1,2 . The receptor on T cells required for the co-stimulatory stimulus involved in the prevention of anergy has not been identified. The human T-cell antigen CD28 provides a signal that can synergize with T-cell antigen receptor stimulation in activating T cells to proliferate and secrete lymphokines 3–6 . Here we report that a monoclonal antibody against the murine homologue of CD28 (ref. 7; J.A.G. et al ., manuscript in preparation) can provide a co-stimulatory signal to naive CD4 + T cells and to T-cell clones. Moreover, we demonstrate that this co-stimulatory signal can block the induction of anergy in T-cell clones.
ISSN:0028-0836
1476-4687
DOI:10.1038/356607a0