C protein (beta gamma) subunit-mediated presynaptic inhibition: Regulation of exocytotic fusion downstream of Ca(2+) entry

The nervous system can modulate neurotransmitter release by neurotransmitter activation of heterotrimeric GTP-binding protein (G protein)-coupled receptors. We found that microinjection of G protein betagamma subunits (Gbetagamma) mimics serotonin's inhibitory effect on neurotransmission.

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2001-04, Vol.292 (5515), p.293-297
Main Authors: Blackmer, Trillium, Larsen, Eric C, Takahashi, Michiko, Martin, Thomas F J
Format: Article
Language:English
Subjects:
Anatomy
Calcium
Inhibition
Nervous system
Proteins
Online Access:Get full text
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Description
Summary:The nervous system can modulate neurotransmitter release by neurotransmitter activation of heterotrimeric GTP-binding protein (G protein)-coupled receptors. We found that microinjection of G protein betagamma subunits (Gbetagamma) mimics serotonin's inhibitory effect on neurotransmission.
ISSN:0036-8075
1095-9203