Dissolved copper triggers cell death in the peripheral mechanosensory system of larval fish

Dissolved copper is an increasingly common non–point source contaminant in urban and urbanizing watersheds. In the present study, we investigated the sublethal effects of dissolved copper on the peripheral mechanosensory system, or lateral line, of larval zebrafish (Danio rerio). Zebrafish larvae we...

Full description

Saved in:
Bibliographic Details
Published in:Environmental toxicology and chemistry 2006-02, Vol.25 (2), p.597-603
Main Authors: Linbo, Tiffany L., Stehr, Carla M., Incardona, John P., Scholz, Nathaniel L.
Format: Article
Language:English
Subjects:
Agnatha. Pisces
Animal reproduction
Animal, plant and microbial ecology
Animals
Applied ecology
Behavior
Behavior, Animal
Biocompatibility
Biological and medical sciences
Biomedical materials
Cell death
Cell Death - drug effects
Cells
Confocal
Contaminants
Copper
Copper - chemistry
Copper - toxicity
Danio rerio
Dissolution
Ecotoxicology, biological effects of pollution
Exposure
Fish
Fluorescence
Freshwater
Fundamental and applied biological sciences. Psychology
General aspects
Histology
Imaging
Larva
Larvae
Lateral line
Mechanoreceptors - cytology
Mechanoreceptors - drug effects
Microscopy
Microscopy, Electron, Scanning
Neurons
Neurotoxicity
Non-point source
Nonpoint source pollution
Presses
Rapids
Solubility
Storm runoff
Storm water
Stormwater
Sublethal effects
Surgical implants
Toxicity
Toxicology
Vertebrates: general zoology, morphology, phylogeny, systematics, cytogenetics, geographical distribution
Water Pollutants - toxicity
Watersheds
Zebrafish
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Dissolved copper is an increasingly common non–point source contaminant in urban and urbanizing watersheds. In the present study, we investigated the sublethal effects of dissolved copper on the peripheral mechanosensory system, or lateral line, of larval zebrafish (Danio rerio). Zebrafish larvae were exposed to copper (0–65 μg/L), and the cytotoxic responses of individual lateral line receptor neurons were examined using a combination of in vivo fluorescence imaging, confocal microscopy, scanning electron microscopy, and conventional histology. Dissolved copper triggered a dose‐dependent loss of neurons in identified lateral line neuromasts at concentrations ≥20 μg/L. The onset of cell death in the larval mechanosensory system was rapid (
ISSN:0730-7268
1552-8618
DOI:10.1897/05-241R.1