Detection of preinvasive cancer cells

More than 85% of all cancers originate in the epithelium that lines the internal surfaces of organs throughout the body. Although these are readily treatable provided they are diagnosed in one of the preinvasive stages, early lesions are often almost impossible to detect. Here we present a new optic...

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Bibliographic Details
Published in:Nature (London) 2000-07, Vol.406 (6791), p.35-36
Main Authors: Feld, M. S, Backman, V, Wallace, M. B, Perelman, L. T, Arendt, J. T, Gurjar, R, Müller, M. G, Zhang, Q, Zonios, G, Kline, E, McGillican, T, Shapshay, S, Valdez, T, Badizadegan, K, Crawford, J. M, Fitzmaurice, M, Kabani, S, Levin, H. S, Seiler, M, Dasari, R. R, Itzkan, I, Van Dam, J
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biopsy
Bladder
brief-communication
Cancer
Carcinoma - pathology
Cell Nucleus - pathology
Colon
Dissemination
Epithelium - pathology
Evaluation Studies as Topic
Humanities and Social Sciences
Humans
Light
Medical sciences
Medical screening
multidisciplinary
Neoplasm Invasiveness
Population density
Precancerous Conditions - pathology
Scattering, Radiation
Science
Science (multidisciplinary)
Spectrum analysis
Spectrum Analysis - methods
Surveillance
Tumor cell
Tumors
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Summary:More than 85% of all cancers originate in the epithelium that lines the internal surfaces of organs throughout the body. Although these are readily treatable provided they are diagnosed in one of the preinvasive stages, early lesions are often almost impossible to detect. Here we present a new optical-probe technique based on light-scattering spectroscopy that is able to detect precancerous and early cancerous changes in cell-rich epithelia.
ISSN:0028-0836
1476-4687
DOI:10.1038/35017638