African Origin of Modern Humans in East Asia: A Tale of 12,000 Y Chromosomes

To test the hypotheses of modern human origin in East Asia, we sampled 12,127 male individuals from 163 populations and typed for three Y chromosome biallelic markers (YAP, M89, and M130). All the individuals carried a mutation at one of the three sites. These three mutations (YAP+, M89T, and M130T)...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2001-05, Vol.292 (5519), p.1151-1153
Main Authors: Ke, Yuehai, Su, Bing, Song, Xiufeng, Lu, Daru, Chen, Lifeng, Li, Hongyu, Qi, Chunjian, Marzuki, Sangkot, Deka, Ranjan, Underhill, Peter, Xiao, Chunjie, Shriver, Mark, Lell, Jeff, Wallace, Douglas, Wells, R Spencer, Seielstad, Mark, Oefner, Peter, Zhu, Dingliang, Jin, Jianzhong, Huang, Wei, Chakraborty, Ranajit, Chen, Zhu, Jin, Li
Format: Article
Language:English
Subjects:
Africa - ethnology
Alleles
Anthropology
Asia
Biological Sciences
Earth sciences
Earth, ocean, space
Exact sciences and technology
Female
Gene Frequency - genetics
Genes
Genetic mutation
Genetics
Germ cells
Haplotypes
Haplotypes - genetics
Hominids
Human beings
Human Y chromosome
Humans
Male
Males
Man
Mice
Molecular Biology
Mutation - genetics
Observation
Origin
Pacific Islands
Paleontology
Phylogeny
Polymorphism, Genetic - genetics
Population Density
Spermatozoa
Testes
Vertebrate paleontology
Y chromosome
Y Chromosome - genetics
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Summary:To test the hypotheses of modern human origin in East Asia, we sampled 12,127 male individuals from 163 populations and typed for three Y chromosome biallelic markers (YAP, M89, and M130). All the individuals carried a mutation at one of the three sites. These three mutations (YAP+, M89T, and M130T) coalesce to another mutation (M168T), which originated in Africa about 35,000 to 89,000 years ago. Therefore, the data do not support even a minimal in situ hominid contribution in the origin of anatomically modern humans in East Asia.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1060011