GlyR [alpha]3: An Essential Target for Spinal PGEsub 2-Mediated Inflammatory Pain Sensitization

Prostaglandin Esub 2 (PGEsub 2) is a crucial mediator of inflammatory pain sensitization. Here, we demonstrate that inhibition of a specific glycine receptor subtype (GlyR [alpha]3) by PCEsub 2-induced receptor phosphorylation underlies central inflammatory pain sensitization. We show that ClyR [alp...

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Published in:Science (American Association for the Advancement of Science) 2004-05, Vol.304 (5672), p.884-887
Main Authors: Harvey, Robert J, Depner, Ulrike B, Wassle, Heinz, Ahmadi, Seifollah
Format: Article
Language:English
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Summary:Prostaglandin Esub 2 (PGEsub 2) is a crucial mediator of inflammatory pain sensitization. Here, we demonstrate that inhibition of a specific glycine receptor subtype (GlyR [alpha]3) by PCEsub 2-induced receptor phosphorylation underlies central inflammatory pain sensitization. We show that ClyR [alpha]3 is distinctly expressed in superficial layers of the spinal cord dorsal horn. Mice deficient in ClyR [alpha]3 not only lack the inhibition of glycinergic neurotransmission by PCEsub 2 seen in wildtype mice but also show a reduction in pain sensitization induced by spinal PGEsub 2 injection or peripheral inflammation. Thus, GlyR [alpha]3 may provide a previously unrecognized molecular target in pain therapy. [PUBLICATION ABSTRACT]
ISSN:0036-8075