Impact of Polymer Tether Length on Multiple Ligand-Receptor Bond Formation

The promoters of cell adhesion are ligands, which are often attached to flexible tethers that bind to surface receptors on adjacent cells. Using a combination of Monte Carlo simulations, diffusion reaction theory, and direct experiments (surface force measurements) of the biotin-streptavidin system,...

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Published in:Science (American Association for the Advancement of Science) 2001-07, Vol.293 (5529), p.465-468
Main Authors: Jeppesen, Claus, Wong, Joyce Y., Kuhl, Tonya L., Israelachvili, Jacob N., Mullah, Nasreen, Zalipsky, Samuel, Marques, Carlos M.
Format: Article
Language:English
Subjects:
Analysis
Biochemistry
Biological and medical sciences
Biotin - chemistry
Biotin - metabolism
Chemical Phenomena
Chemistry, Physical
Dielectric materials
Diffusion
Electrons
Fundamental and applied biological sciences. Psychology
Interactions. Associations
Intermolecular phenomena
Kinetics
Ligand binding (Biochemistry)
Ligands
Mathematics
Molecular biophysics
Molecular Structure
Molecules
Monte Carlo Method
Monte Carlo Methods
Oxides
Polyethylene Glycols
Polymers
Polymers - chemistry
Protein Conformation
Receptors
Semiconductors
Silicon
Solvents
Streptavidin - chemistry
Streptavidin - metabolism
Surface Properties
Thermodynamics
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container_issue 5529
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container_title Science (American Association for the Advancement of Science)
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Israelachvili, Jacob N.
Mullah, Nasreen
Zalipsky, Samuel
Marques, Carlos M.
description The promoters of cell adhesion are ligands, which are often attached to flexible tethers that bind to surface receptors on adjacent cells. Using a combination of Monte Carlo simulations, diffusion reaction theory, and direct experiments (surface force measurements) of the biotin-streptavidin system, we have quantified polymer chain dynamics and the kinetics and spatial range of tethered ligand-receptor binding. The results show that the efficiency of strong binding does not depend solely on the molecular architecture or binding energy of the receptor-ligand pair, nor on the equilibrium configuration of the polymer tether, but rather on its "rare" extended conformations.
doi_str_mv 10.1126/science.293.5529.465
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subjects Analysis
Biochemistry
Biological and medical sciences
Biotin - chemistry
Biotin - metabolism
Chemical Phenomena
Chemistry, Physical
Dielectric materials
Diffusion
Electrons
Fundamental and applied biological sciences. Psychology
Interactions. Associations
Intermolecular phenomena
Kinetics
Ligand binding (Biochemistry)
Ligands
Mathematics
Molecular biophysics
Molecular Structure
Molecules
Monte Carlo Method
Monte Carlo Methods
Oxides
Polyethylene Glycols
Polymers
Polymers - chemistry
Protein Conformation
Receptors
Semiconductors
Silicon
Solvents
Streptavidin - chemistry
Streptavidin - metabolism
Surface Properties
Thermodynamics
title Impact of Polymer Tether Length on Multiple Ligand-Receptor Bond Formation
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