Genetics of body-weight regulation

The role of genetics in obesity is twofold. Studying rare mutations in humans and model organisms provides fundamental insight into a complex physiological process, and complements population-based studies that seek to reveal primary causes. Remarkable progress has been made on both fronts, and the...

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Bibliographic Details
Published in:Nature (London) 2000-04, Vol.404 (6778), p.644-651
Main Authors: Barsh, Gregory S, Farooqi, I. Sadaf, O'Rahilly, Stephen
Format: Article
Language:English
Subjects:
Animals
Body Weight - genetics
Forecasting
Genetic Predisposition to Disease
Genetics
Humanities and Social Sciences
Humans
Models, Genetic
multidisciplinary
Mutation
Obesity
Obesity - genetics
Physiology
Population studies
review-article
Rodent Diseases - genetics
Science
Science (multidisciplinary)
Weight control
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Summary:The role of genetics in obesity is twofold. Studying rare mutations in humans and model organisms provides fundamental insight into a complex physiological process, and complements population-based studies that seek to reveal primary causes. Remarkable progress has been made on both fronts, and the pace of advance is likely to accelerate as functional genomics and the human genome project expand and mature. Approaches based on mendelian and quantitative genetics may well converge, and lead ultimately to more rational and selective therapies.
ISSN:0028-0836
1476-4687
DOI:10.1038/35007519