HIV Vaccine Trial Justified

McNeil et al fully agree in Burton et al's recent Policy Forum, which states that phase III trials alone are required to establish the efficacy of HIV vaccines. However, McNeil et al disagree with the position of the authors regarding their sponsorship of a recently initiated HIV vaccine effica...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2004-02, Vol.303 (5660), p.961-961
Main Authors: McNeil, John G., Johnston, Margaret I., Birx, Deborah L., Tramont, Edmund C.
Format: Article
Language:English
Subjects:
AIDS vaccines
Clinical trials
Experimentation
Feedback (Response)
HIV
Human immunodeficiency virus
Laboratories
Policy Forum
Product development
Scientific Principles
T lymphocytes
Testing
Vaccination
Vaccines
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Summary:McNeil et al fully agree in Burton et al's recent Policy Forum, which states that phase III trials alone are required to establish the efficacy of HIV vaccines. However, McNeil et al disagree with the position of the authors regarding their sponsorship of a recently initiated HIV vaccine efficacy trial in Thailand. They detail the initiation of the phase III efficacy trial of a combination vaccine regimen, referred to as "prime-boost," in Thailand and conclude that the ongoing prime-boost trial is scientifically justified, morally correct, and strategically important.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1096161