How does morphine work?

A study shows that mice lacking the mu-opioid receptor (MOR) do not show any of the normal responses to morphine and do not become dependent on the drug after repeated treatment with it. These findings point to the MOR as the principal mediator of the pharmacological effects of morphine.

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Bibliographic Details
Published in:Nature (London) 1996-10, Vol.383 (6603), p.759-760
Main Author: Iversen, Leslie L
Format: Article
Language:English
Subjects:
Analgesics, Opioid - metabolism
Analgesics, Opioid - pharmacology
Animals
Humanities and Social Sciences
Mice
Mice, Knockout
Morphine - metabolism
Morphine - pharmacology
Morphine Dependence - metabolism
multidisciplinary
Narcotics
Narcotics - metabolism
Narcotics - pharmacology
Nervous system
news-and-views
Pharmacology
Receptors, Opioid, mu - metabolism
Rodents
Science
Science (multidisciplinary)
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Description
Summary:A study shows that mice lacking the mu-opioid receptor (MOR) do not show any of the normal responses to morphine and do not become dependent on the drug after repeated treatment with it. These findings point to the MOR as the principal mediator of the pharmacological effects of morphine.
ISSN:0028-0836
1476-4687
DOI:10.1038/383759a0