Kinetic model for separation of particle mixtures by interfacial partitioning

A mechanistic study is presented on the partition behavior of mixtures of particles in interfacial partitioning with liquid two‐phase systems. A model is developed based on a mechanism of competitive adsorption of particles at the liquid‐liquid interface. In this model, it is assumed that partitioni...

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Bibliographic Details
Published in:AIChE journal 2004-06, Vol.50 (6), p.1156-1168
Main Authors: Hoeben, M. A., van der Lans, R. G. J. M., van der Wielen, L. A. M., Kwant, G.
Format: Article
Language:English
Subjects:
Adsorption
Applied sciences
Chemical engineering
crystals
Exact sciences and technology
interfacial partitioning
Kinetics
Langmuir-isotherm
Liquids
particle recovery
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Summary:A mechanistic study is presented on the partition behavior of mixtures of particles in interfacial partitioning with liquid two‐phase systems. A model is developed based on a mechanism of competitive adsorption of particles at the liquid‐liquid interface. In this model, it is assumed that partitioning is the result of a dynamic process of continuous adsorption and desorption of particles at droplet interfaces. It is shown that under certain conditions such a process can be described by means of Langmuir‐type adsorption isotherms. The model is tested with partition data of mixtures of ampicillin and phenylglycine crystals in a water/n‐pentane system, which leads to a reasonable quantitative description. The results indicate that for this particular system, adsorption of crystals at the interface occurs up to amounts that are needed for a monolayer coverage. In case larger amounts of crystals are present, partitioning of particles is subject to a competition for the available interfacial area. In such a case, the kinetics of adsorption and desorption of the particles to the interface seem to differ from a situation where the interface is partly uncovered. © 2004 American Institute of Chemical Engineers AIChE J, 50: 1156–1168, 2004
ISSN:0001-1541
1547-5905
DOI:10.1002/aic.10105