A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum

Lipids are not encoded by a DNA template and therefore cannot be mutated, knocked out or knocked down. This by no means renders them impotent from a cell biological perspective. Here I propose a model for the involvement of lipid rearrangements in the execution of crucial steps in (glyco)protein qua...

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Bibliographic Details
Published in:Nature 2007-07, Vol.448 (7152), p.435-438
Main Author: Ploegh, Hidde L
Format: Article
Language:English
Subjects:
Biological
Biological and medical sciences
Biological Transport
Cell physiology
Cellular biology
Deoxyribonucleic acid
DNA
Endoplasmic reticulum
Endoplasmic Reticulum - chemistry
Endoplasmic Reticulum - metabolism
Endoplasmic Reticulum - virology
Escape structures
Fundamental and applied biological sciences. Psychology
Genetic aspects
Glycoproteins
Glycoproteins - chemistry
Glycoproteins - metabolism
Hatches
Humanities and Social Sciences
Lipid Metabolism
Lipids
Lipids - biosynthesis
Lipids - chemistry
Membrane and intracellular transports
Models, Biological
Molecular and cellular biology
multidisciplinary
Mutation
Properties
Protein Folding
Quality control
Science
Science (multidisciplinary)
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Description
Summary:Lipids are not encoded by a DNA template and therefore cannot be mutated, knocked out or knocked down. This by no means renders them impotent from a cell biological perspective. Here I propose a model for the involvement of lipid rearrangements in the execution of crucial steps in (glyco)protein quality control.
ISSN:0028-0836
1476-4687
1476-4679
DOI:10.1038/nature06004