A Microfluidic Device for Conducting Gas-Liquid-Solid Hydrogenation Reactions

We have developed an efficient system for triphase reactions using a microchannel reactor. Using this system, we conducted hydrogenation reactions that proceeded smoothly to afford the desired products quantitatively within 2 minutes for a variety of substrates. The system could also be applied to d...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2004-05, Vol.304 (5675), p.1305-1308
Main Authors: Kobayashi, Juta, Mori, Yuichiro, Okamoto, Kuniaki, Akiyama, Ryo, Ueno, Masaharu, Kitamori, Takehiko, Kobayashi, Shū
Format: Article
Language:English
Subjects:
Applied sciences
Catalysis
Catalysts
Catalytic reactions
Chemical engineering
Chemical reactions
Chemical reactors
Chemistry
Diffusion
Equipment and supplies
Ethers
Exact sciences and technology
Flow velocity
General and physical chemistry
Hydrogenation
Liquids
Nuclear reactors
Organic Chemistry
Palladium
Reaction Time
Reactivity
Reactors
Reagents
Scientific equipment
Scientific equipment and supplies
Solids
Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry
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Summary:We have developed an efficient system for triphase reactions using a microchannel reactor. Using this system, we conducted hydrogenation reactions that proceeded smoothly to afford the desired products quantitatively within 2 minutes for a variety of substrates. The system could also be applied to deprotection reactions. We could achieve an effective interaction between hydrogen, substrates, and a palladium catalyst using extremely large interfacial areas and the short path required for molecular diffusion in the very narrow channel space. This concept could be extended to other multiphase reactions that use gas-phase reagents such as oxygen and carbon dioxide.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1096956