Microbial production of dihydroxyacetone

Dihydroxyacetone is extensively used in cosmetic industry as an artificial suntan besides having clinical and biological applications. Thus, it is important to meet the commercial demand of dihydroxyacetone at an economical and qualitative level. Microbial route of production is found to be more fav...

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Bibliographic Details
Published in:Biotechnology advances 2008-07, Vol.26 (4), p.293-303
Main Authors: MISHRA, Ruchi, SEEMA RANI JAIN, KUMAR, Ashok
Format: Article
Language:English
Subjects:
Bacteria - cytology
Bacteria - metabolism
Biological and medical sciences
Biotechnology
Cell Membrane - metabolism
Cytoplasm - metabolism
Dihydroxyacetone - biosynthesis
Dihydroxyacetone - chemical synthesis
Fermentation
Fundamental and applied biological sciences. Psychology
Gluconobacter oxydans
Glycerol - metabolism
Humans
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Summary:Dihydroxyacetone is extensively used in cosmetic industry as an artificial suntan besides having clinical and biological applications. Thus, it is important to meet the commercial demand of dihydroxyacetone at an economical and qualitative level. Microbial route of production is found to be more favorable for dihydroxyacetone as compared to chemical methods. This review gives detailed information about the microbial route of dihydroxyacetone production. Till date the microorganism which is most utilized for dihydroxyacetone production is Gluconobacter oxydans. Some limitations associated with dihydroxyacetone production by G. oxydans like substrate inhibition, product inhibition and oxygen limitation are discussed here. Various fermentation modes and culture conditions have been tried for their ability to overcome these limitations. It has been found that fed-batch mode of fermentation provides a better yield as compared to batch mode for dihydroxyacetone production. Two-stage repeated fed-batch mode of fermentation has been found to be the most optimized mode. Immobilization has also been recognized as a much better alternative for fermentation since it avoids the problem of substrate and product inhibition to a greater extent. Although these methods have increased the dihydroxyacetone production to a prominent level yet the production has not reached the level required to meet the commercial demand. One looks for future prospects of developing recombinant microbial method for dihydoxyacetone production.
ISSN:0734-9750
1873-1899
DOI:10.1016/j.biotechadv.2008.02.001