Micellar Nanocontainers Distribute to Defined Cytoplasmic Organelles

Block copolymer micelles are water-soluble biocompatible nanocontainers with great potential for delivering hydrophobic drugs. An understanding of their cellular distribution is essential to achieving selective delivery of drugs at the subcellular level. Triple-labeling confocal microscopy in live c...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2003-04, Vol.300 (5619), p.615-618
Main Authors: Savić, Radoslav, Luo, Laibin, Eisenberg, Adi, Maysinger, Dusica
Format: Article
Language:English
Subjects:
3T3 cells
Animals
Azides - chemistry
B lymphocytes
Biocompatible Materials
Biological and medical sciences
Block copolymers
Cell membranes
Cell Nucleus - metabolism
Cellular biology
Chemical properties
Cytoplasm - metabolism
Delivery Systems
Diffusion
Drug Carriers - chemistry
Drug Carriers - metabolism
Drug delivery systems
Drug targeting
Drug Therapy
Drugs
Dyes
Endoplasmic Reticulum - metabolism
Ethylene Oxide - chemistry
Ethylene Oxide - metabolism
Fluoresceins
Fluorescence
General pharmacology
Golgi Apparatus - metabolism
Hydrophobic and Hydrophilic Interactions
Lactones - chemistry
Lactones - metabolism
Lysosomes - metabolism
Medical sciences
Micelles
Microscopy, Confocal
Microscopy, Fluorescence
Miscellaneous
Mitochondria - metabolism
Nanotechnology
Narcotics
Organelles
Organelles - metabolism
PC12 Cells
Pharmacology. Drug treatments
Polyethylene Glycols - chemistry
Polymers
Polymers - chemistry
Polymers - metabolism
Rats
Rhodamines - chemistry
Solubility
Spectrometry, Fluorescence
Vehicles
Water
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Summary:Block copolymer micelles are water-soluble biocompatible nanocontainers with great potential for delivering hydrophobic drugs. An understanding of their cellular distribution is essential to achieving selective delivery of drugs at the subcellular level. Triple-labeling confocal microscopy in live cells revealed the localization of micelles in several cytoplasmic organelles, including mitochondria, but not in the nucleus. Moreover, micelles change the cellular distribution of and increase the amount of the agent delivered to the cells. These micelles may thus be worth exploring for their potential to selectively deliver drugs to specified subcellular targets.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1078192