Alteration of the Phase and Period of a Circadian Oscillator by a Reversible Transcription Inhibitor

A function for transcription in the mechanism of a circadian oscillator was investigated with the reversible transcription inhibitor 5,6-dichloro-1-β-D-ribobenzimidazole (DRB). Two-hour treatments with DRB shifted the phase of the circadian rhythm of the isolated eye of Aplysia, and continuous treat...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1991-08, Vol.253 (5020), p.673-675
Main Authors: Raju, Uma, Koumenis, Constantinos, Nunez-Regueiro, Marta, Eskin, Arnold
Format: Article
Language:English
Subjects:
Animals
Aplysia
Biochemistry
Biological and medical sciences
Biological clocks
Camptothecin - pharmacology
Cellular biology
Circadian rhythm
Circadian Rhythm - radiation effects
Circadian rhythms
Delay lines
Dichlororibofuranosylbenzimidazole - pharmacology
Eye - drug effects
Eyes
Fundamental and applied biological sciences. Psychology
Genetic transcription
In Vitro Techniques
Mechanical oscillators
Messenger RNA
Molecular and cellular biology
Molecular genetics
Ocular Physiological Phenomena
Oscillators
Phase shift
Protein synthesis
RNA
Time Factors
Transcription (Genetics)
Transcription, Genetic - drug effects
Transcription. Transcription factor. Splicing. Rna processing
Uridine - metabolism
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Summary:A function for transcription in the mechanism of a circadian oscillator was investigated with the reversible transcription inhibitor 5,6-dichloro-1-β-D-ribobenzimidazole (DRB). Two-hour treatments with DRB shifted the phase of the circadian rhythm of the isolated eye of Aplysia, and continuous treatments of DRB lengthened the free running period of this rhythm. Camptothecin, an inhibitor of transcription that is structurally unrelated to DRB, had similar effects on the circadian rhythm. These results suggest that transcription may be part of the circadian oscillating mechanism.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1871602