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Alteration of the Phase and Period of a Circadian Oscillator by a Reversible Transcription Inhibitor
A function for transcription in the mechanism of a circadian oscillator was investigated with the reversible transcription inhibitor 5,6-dichloro-1-β-D-ribobenzimidazole (DRB). Two-hour treatments with DRB shifted the phase of the circadian rhythm of the isolated eye of Aplysia, and continuous treat...
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Published in: | Science (American Association for the Advancement of Science) 1991-08, Vol.253 (5020), p.673-675 |
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creator | Raju, Uma Koumenis, Constantinos Nunez-Regueiro, Marta Eskin, Arnold |
description | A function for transcription in the mechanism of a circadian oscillator was investigated with the reversible transcription inhibitor 5,6-dichloro-1-β-D-ribobenzimidazole (DRB). Two-hour treatments with DRB shifted the phase of the circadian rhythm of the isolated eye of Aplysia, and continuous treatments of DRB lengthened the free running period of this rhythm. Camptothecin, an inhibitor of transcription that is structurally unrelated to DRB, had similar effects on the circadian rhythm. These results suggest that transcription may be part of the circadian oscillating mechanism. |
doi_str_mv | 10.1126/science.1871602 |
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Two-hour treatments with DRB shifted the phase of the circadian rhythm of the isolated eye of Aplysia, and continuous treatments of DRB lengthened the free running period of this rhythm. Camptothecin, an inhibitor of transcription that is structurally unrelated to DRB, had similar effects on the circadian rhythm. These results suggest that transcription may be part of the circadian oscillating mechanism.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1871602</identifier><identifier>PMID: 1871602</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Society for the Advancement of Science</publisher><subject>Animals ; Aplysia ; Biochemistry ; Biological and medical sciences ; Biological clocks ; Camptothecin - pharmacology ; Cellular biology ; Circadian rhythm ; Circadian Rhythm - radiation effects ; Circadian rhythms ; Delay lines ; Dichlororibofuranosylbenzimidazole - pharmacology ; Eye - drug effects ; Eyes ; Fundamental and applied biological sciences. Psychology ; Genetic transcription ; In Vitro Techniques ; Mechanical oscillators ; Messenger RNA ; Molecular and cellular biology ; Molecular genetics ; Ocular Physiological Phenomena ; Oscillators ; Phase shift ; Protein synthesis ; RNA ; Time Factors ; Transcription (Genetics) ; Transcription, Genetic - drug effects ; Transcription. Transcription factor. Splicing. 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Two-hour treatments with DRB shifted the phase of the circadian rhythm of the isolated eye of Aplysia, and continuous treatments of DRB lengthened the free running period of this rhythm. Camptothecin, an inhibitor of transcription that is structurally unrelated to DRB, had similar effects on the circadian rhythm. These results suggest that transcription may be part of the circadian oscillating mechanism.</description><subject>Animals</subject><subject>Aplysia</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Biological clocks</subject><subject>Camptothecin - pharmacology</subject><subject>Cellular biology</subject><subject>Circadian rhythm</subject><subject>Circadian Rhythm - radiation effects</subject><subject>Circadian rhythms</subject><subject>Delay lines</subject><subject>Dichlororibofuranosylbenzimidazole - pharmacology</subject><subject>Eye - drug effects</subject><subject>Eyes</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic transcription</subject><subject>In Vitro Techniques</subject><subject>Mechanical oscillators</subject><subject>Messenger RNA</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Ocular Physiological Phenomena</subject><subject>Oscillators</subject><subject>Phase shift</subject><subject>Protein synthesis</subject><subject>RNA</subject><subject>Time Factors</subject><subject>Transcription (Genetics)</subject><subject>Transcription, Genetic - drug effects</subject><subject>Transcription. Transcription factor. Splicing. 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Two-hour treatments with DRB shifted the phase of the circadian rhythm of the isolated eye of Aplysia, and continuous treatments of DRB lengthened the free running period of this rhythm. Camptothecin, an inhibitor of transcription that is structurally unrelated to DRB, had similar effects on the circadian rhythm. These results suggest that transcription may be part of the circadian oscillating mechanism.</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>1871602</pmid><doi>10.1126/science.1871602</doi><tpages>3</tpages></addata></record> |
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subjects | Animals Aplysia Biochemistry Biological and medical sciences Biological clocks Camptothecin - pharmacology Cellular biology Circadian rhythm Circadian Rhythm - radiation effects Circadian rhythms Delay lines Dichlororibofuranosylbenzimidazole - pharmacology Eye - drug effects Eyes Fundamental and applied biological sciences. Psychology Genetic transcription In Vitro Techniques Mechanical oscillators Messenger RNA Molecular and cellular biology Molecular genetics Ocular Physiological Phenomena Oscillators Phase shift Protein synthesis RNA Time Factors Transcription (Genetics) Transcription, Genetic - drug effects Transcription. Transcription factor. Splicing. Rna processing Uridine - metabolism |
title | Alteration of the Phase and Period of a Circadian Oscillator by a Reversible Transcription Inhibitor |
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