Molecular Evolution of Protein Atomic Composition

Living organisms encounter various growth conditions in their habitats, raising the question of whether ecological fluctuations could alter biological macromolecules. The advent of complete genome sequences and the characterization of whole metabolic pathways allowed us to search for such ecological...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2001-07, Vol.293 (5528), p.297-300
Main Authors: Baudouin-Cornu, Peggy, Surdin-Kerjan, Yolande, Marlière, Philippe, Thomas, Dominique
Format: Article
Language:English
Subjects:
Amino acids
Animals
Atoms
Bacterial Proteins - chemistry
Bacterial Proteins - genetics
Bacteriology
Biological and medical sciences
Biological evolution
Brackish
Carbon
Carbon - analysis
carbon-assimilatory enzymes
Chemical composition
Coding
ecological genetics
Ecology
Enzymes
Escherichia coli
Escherichia coli - chemistry
Escherichia coli - enzymology
Escherichia coli - genetics
Evolution, Molecular
Freshwater
Fundamental and applied biological sciences. Psychology
Fungal Proteins - chemistry
Fungal Proteins - genetics
General aspects
Genetics of eukaryotes. Biological and molecular evolution
Genomics
Habitats
Humans
Marine
Metabolism
Microbiology
molecular evolution
Molecules
Nitrogen
Nitrogen - analysis
Physiological assimilation
protein atomic composition
Protein metabolism
Proteins
Rats
Saccharomyces cerevisiae
Saccharomyces cerevisiae - chemistry
Saccharomyces cerevisiae - enzymology
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - metabolism
Statistical Significance
Sulfur
Sulfur - analysis
sulfur-assimilatory enzymes
Yeasts
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Summary:Living organisms encounter various growth conditions in their habitats, raising the question of whether ecological fluctuations could alter biological macromolecules. The advent of complete genome sequences and the characterization of whole metabolic pathways allowed us to search for such ecological imprints. Significant correlations between atomic composition and metabolic function were found in sulfur- and carbon-assimilatory enzymes, which appear depleted in sulfur and carbon, respectively, in both the bacterium Escherichia coli and the eukaryote Saccharomyces cerevisiae. In addition to genetic instructions, genomic data thus also provide paleontological records of environmental nutrient availability and of metabolic costs.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1061052