Molecular Hydrogen as an Energy Source for Helicobacter pylori

The gastric pathogen Helicobacter pylori is known to be able to use molecular hydrogen as a respiratory substrate when grown in the laboratory. We found that hydrogen is available in the gastric mucosa of mice and that its use greatly increased the stomach colonization by H. pylori. Hydrogenase acti...

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Published in:Science (American Association for the Advancement of Science) 2002-11, Vol.298 (5599), p.1788-1790
Main Authors: Olson, Jonathan W., Maier, Robert J.
Format: Article
Language:English
Subjects:
Animals
Bacteria
Bacteriology
Biological and medical sciences
Catechol 2,3-Dioxygenase
Colon - metabolism
Colon - microbiology
Dioxygenases
Energy
Energy Metabolism
Energy sources
Fermentation
Fundamental and applied biological sciences. Psychology
Gastric Mucosa - metabolism
Gastric Mucosa - microbiology
Gene Expression Regulation, Bacterial
Genes
Genes, Reporter
Helicobacter pylori
Helicobacter pylori - growth & development
Helicobacter pylori - metabolism
Hydrogen
Hydrogen - metabolism
Hydrogenase - genetics
Hydrogenase - metabolism
Kinetics
Land Settlement
Mice
Microbial colonization
Microbiology
Mutation
Oxidation
Oxidation-Reduction
Oxygenases - genetics
Oxygenases - metabolism
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
Pathogens
Plasmids
Stomach
Transcription, Genetic
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container_issue 5599
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container_title Science (American Association for the Advancement of Science)
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creator Olson, Jonathan W.
Maier, Robert J.
description The gastric pathogen Helicobacter pylori is known to be able to use molecular hydrogen as a respiratory substrate when grown in the laboratory. We found that hydrogen is available in the gastric mucosa of mice and that its use greatly increased the stomach colonization by H. pylori. Hydrogenase activity in H. pylori is constitutive but increased fivefold upon incubation with hydrogen. Hydrogen concentrations measured in the stomachs of live mice were found to be 10 to 50 times as high as the H. pylori affinity for hydrogen. A hydrogenase mutant strain is much less efficient in its colonization of mice. Therefore, hydrogen present in animals as a consequence of normal colonic flora is an energy-yielding substrate that can facilitate the maintenance of a pathogenic bacterium.
doi_str_mv 10.1126/science.1077123
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subjects Animals
Bacteria
Bacteriology
Biological and medical sciences
Catechol 2,3-Dioxygenase
Colon - metabolism
Colon - microbiology
Dioxygenases
Energy
Energy Metabolism
Energy sources
Fermentation
Fundamental and applied biological sciences. Psychology
Gastric Mucosa - metabolism
Gastric Mucosa - microbiology
Gene Expression Regulation, Bacterial
Genes
Genes, Reporter
Helicobacter pylori
Helicobacter pylori - growth & development
Helicobacter pylori - metabolism
Hydrogen
Hydrogen - metabolism
Hydrogenase - genetics
Hydrogenase - metabolism
Kinetics
Land Settlement
Mice
Microbial colonization
Microbiology
Mutation
Oxidation
Oxidation-Reduction
Oxygenases - genetics
Oxygenases - metabolism
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
Pathogens
Plasmids
Stomach
Transcription, Genetic
title Molecular Hydrogen as an Energy Source for Helicobacter pylori
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