Multigenerational Cortical Inheritance of the Rax2 Protein in Orienting Polarity and Division in Yeast

Diploid yeast cells repeatedly polarize and bud from their poles, probably because of highly stable marks of unknown composition. Here, Rax2, a membrane protein, was shown to behave as such a mark. The Rax2 protein itself was inherited immutably at the cell cortex for multiple generations, and Rax2...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2000-12, Vol.290 (5498), p.1975-1978
Main Authors: Chen, Tracy, Hiroko, Takatoshi, Chaudhuri, Amitabha, Inose, Fumika, Lord, Matthew, Tanaka, Shigeko, Chant, John, Fujita, Atsushi
Format: Article
Language:English
Subjects:
Biological and medical sciences
Brain
Budding
Cell cycle
Cell Division
Cell Polarity
Cell research
Cells
Cells (Biology)
Cytological research
Cytoskeletal proteins
Diploidy
Fundamental and applied biological sciences. Psychology
Fungal Proteins - genetics
Fungal Proteins - metabolism
Growth
Growth, nutrition, metabolism, transports, enzymes. Molecular biology
Haploidy
Logical Thinking
Membrane Proteins - genetics
Membrane Proteins - metabolism
Microbiology
Microfilaments
Morphogenesis
Mothers
Mutation
Mycology
Newborns
Observations
Phenotype
Photoreceptors
Polarity (Biology)
Proteins
Rax2 protein
Recombinant Fusion Proteins - metabolism
Repression
Saccharomyces cerevisiae
Scars
Site Selection
Yeast
Yeast (Food product)
Yeasts - cytology
Yeasts - genetics
Yeasts - growth & development
Yeasts - metabolism
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Description
Summary:Diploid yeast cells repeatedly polarize and bud from their poles, probably because of highly stable marks of unknown composition. Here, Rax2, a membrane protein, was shown to behave as such a mark. The Rax2 protein itself was inherited immutably at the cell cortex for multiple generations, and Rax2 was shown to have a half-life exceeding several generations. The persistent inheritance of cortical protein markers would provide a means to couple a cell's history to the future development of a precise morphogenetic form.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.290.5498.1975