Immunity, Inflammation, and Allergy in the Gut

The gut immune system has the challenge of responding to pathogens while remaining relatively unresponsive to food antigens and the commensal microflora. In the developed world, this ability appears to be breaking down, with chronic inflammatory diseases of the gut commonplace in the apparent absenc...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2005-03, Vol.307 (5717), p.1920-1925
Main Authors: MacDonald, Thomas T, Monteleone, Giovanni
Format: Article
Language:English
Subjects:
Allergic reaction
Allergies
Allergy
Animals
Antigens
Antigens, Bacterial - immunology
Bacteria
Bacteria - immunology
Bacterial Physiological Phenomena
Care and treatment
Celiac disease
Celiac Disease - immunology
Celiac Disease - pathology
Celiac Disease - physiopathology
Commensals
Communicable diseases
Crohn disease
Digestive system
Epithelial cells
Flora
Food Hypersensitivity
Gastrointestinal diseases
Gastrointestinal system
Glutens - immunology
Homeostasis
Humans
Immune system
Immunity
Immunity (Physiology)
Immunity, Mucosal
Inflammation
Inflammatory Bowel Diseases - immunology
Inflammatory Bowel Diseases - pathology
Inflammatory Bowel Diseases - physiopathology
Inflammatory Bowel Diseases - therapy
Intestinal Mucosa - immunology
Intestinal Mucosa - physiology
Intestines - immunology
Intestines - microbiology
Intestines - physiology
Mutation
Pattern Recognition
Permeability
Reviews
Scientific Concepts
T lymphocytes
T-Lymphocytes - immunology
Ulcerative colitis
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Summary:The gut immune system has the challenge of responding to pathogens while remaining relatively unresponsive to food antigens and the commensal microflora. In the developed world, this ability appears to be breaking down, with chronic inflammatory diseases of the gut commonplace in the apparent absence of overt infections. In both mouse and man, mutations in genes that control innate immune recognition, adaptive immunity, and epithelial permeability are all associated with gut inflammation. This suggests that perturbing homeostasis between gut antigens and host immunity represents a critical determinant in the development of gut inflammation and allergy.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1106442