Mammalian SAD Kinases Are Required for Neuronal Polarization

Electrical activity in neurons is generally initiated in dendritic processes then propagated along axons to synapses, where it is passed to other neurons. Major structural features of neurons--their dendrites and axons--are thus related to their fundamental functions: the receipt and transmission of...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2005-02, Vol.307 (5711), p.929-932
Main Authors: Kishi, Masashi, Pan, Y. Albert, Crump, Justin Gage, Sanes, Joshua R
Format: Article
Language:English
Subjects:
Adults
Anatomy
Animals
Antibodies
Apoptosis
Axons
Axons - physiology
Axons - ultrastructure
Biochemistry. Physiology. Immunology. Molecular biology
Biological and medical sciences
Brain
Brain - cytology
Brain - embryology
Brain - metabolism
Brain Chemistry
Caenorhabditis elegans
Cell Differentiation
Cell Line
Cell Polarity
Cell Shape
Cells, Cultured
Cerebral Cortex - cytology
Cerebral Cortex - embryology
Cerebral Cortex - metabolism
Dendrites
Dendrites - physiology
Dendrites - ultrastructure
Fundamental and applied biological sciences. Psychology
Hippocampus - cytology
Individualized Instruction
Invertebrates
Mammalia
Mammals
Mice
Microtubule-Associated Proteins - metabolism
Microtubules
Mutation
Nemathelminthia. Plathelmintha
Neurites
Neurology
Neurons
Neurons - cytology
Neurons - physiology
Neurons - ultrastructure
Neuroscience
Phosphorylation
Physiology. Development
Prosencephalon - cytology
Prosencephalon - embryology
Prosencephalon - metabolism
Protein-Serine-Threonine Kinases - genetics
Protein-Serine-Threonine Kinases - physiology
Proteins
Spinal Cord - chemistry
Spinal Cord - embryology
tau Proteins - metabolism
Vertebrates
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Description
Summary:Electrical activity in neurons is generally initiated in dendritic processes then propagated along axons to synapses, where it is passed to other neurons. Major structural features of neurons--their dendrites and axons--are thus related to their fundamental functions: the receipt and transmission of information. The acquisition of these distinct properties by dendrites and axons, called polarization, is a critical step in neuronal differentiation. We show here that SAD-A and SAD-B, mammalian orthologs of a kinase needed for presynaptic differentiation in Caenorhabditis elegans, are required for neuronal polarization. These kinases will provide entry points for unraveling signaling mechanisms that polarize neurons.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1107403