Mammalian Vestibular Hair Cell Regeneration

Rubel, Dew and Roberson contend that Warchol et al and Forge et al's conclusions that the vestibular epithelium of the mature mammalian inner ear may have the ability to produce new hair cells after aminoglycoside injury do not provide convincing evidence that the DNA labeling is the source of...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1995-02, Vol.267 (5198), p.701-707
Main Authors: Rubel, Edwin W., Dew, Leigh Anne, Roberson, David W., Warchol, Mark E., Corwin, Jeffrey T., Forge, Andrew, Li, Lin, Nevill, Graham
Format: Article
Language:English
Subjects:
Animals
Antibiotics
Cell Count
Cell Division
Cell growth
Cell nucleus
Cellular biology
Cilia - ultrastructure
Control Groups
Cultured cells
Daughter cells
Deoxyribonucleic acid
DNA
DNA - biosynthesis
Epithelium
Gentamicins - toxicity
Guinea Pigs
Hair
Hair cells
Hair Cells, Auditory - cytology
Hair Cells, Auditory - drug effects
Hair Cells, Auditory - physiology
Injuries
Labyrinth (Ear)
Mammalia
Mammals
Microscopy, Electron, Scanning
Regeneration
Regeneration (Biology)
Saccule and Utricle - cytology
Saccule and Utricle - drug effects
Saccule and Utricle - physiology
Stromal cells
Technical Comments
Vestibular apparatus
Vestibule (Ear)
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Summary:Rubel, Dew and Roberson contend that Warchol et al and Forge et al's conclusions that the vestibular epithelium of the mature mammalian inner ear may have the ability to produce new hair cells after aminoglycoside injury do not provide convincing evidence that the DNA labeling is the source of the apparent hair cell recovery. Warchol et al and Forge et al respond to Rubel, Dew and Roberson's criticisms.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.7839150