Impaired energy homeostasis in C/EBPalpha knockout mice

Mice homozygous for the targeted deletion of the c/ebpalpha gene did not store hepatic glycogen and died from hypoglycemia within eight hours after birth. A study demonstrates the C/EBPalpha, a CCAAT/enhancer-binding protein, is critical for the establishment and maintenance of energy homeostasis in...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1995-08, Vol.269 (5227), p.1108-1108
Main Authors: Wang, Nai-dy, Finegold, Milton J, Bradley, Allan, Ou, Ching N
Format: Article
Language:English
Subjects:
Babies
Energy
Hypoglycemia
Metabolism
Neonates
Pregnancy
Proteins
Online Access:Get full text
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Summary:Mice homozygous for the targeted deletion of the c/ebpalpha gene did not store hepatic glycogen and died from hypoglycemia within eight hours after birth. A study demonstrates the C/EBPalpha, a CCAAT/enhancer-binding protein, is critical for the establishment and maintenance of energy homeostasis in neonates.
ISSN:0036-8075
1095-9203