Maintained Cardiac Pumping in Anoxic Crucian Carp

Like most vertebrates, humans die within minutes when deprived of molecular oxygen (anoxia), in part because of cardiac failure. In contrast, some freshwater turtles can survive anoxia for months at low temperatures, but to do so, they drastically suppress cardiac activity and autonomic cardiovascul...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2004-10, Vol.306 (5693), p.77-77
Main Authors: Jonathan A. W. Stecyk, Stensløkken, Kåre-Olav, Farrell, Anthony P., Nilsson, Göran E.
Format: Article
Language:English
Subjects:
Anatomy
Animal behavior
Animals
Anoxia
Autonomic Nervous System - physiology
Blood Pressure
Brevia
Carassius carassius
Cardiac Output
Cardiovascular disease
Carp
Carps
Carps - physiology
Ethanol
Ethanol - metabolism
Fish
Freshwater
Heart - physiology
Heart Rate
Hemodynamics
Hypoxia
Hypoxia - physiopathology
Physiological aspects
Respiration
Statistical Analysis
Stroke Volume
Turtles
Vascular Resistance
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Summary:Like most vertebrates, humans die within minutes when deprived of molecular oxygen (anoxia), in part because of cardiac failure. In contrast, some freshwater turtles can survive anoxia for months at low temperatures, but to do so, they drastically suppress cardiac activity and autonomic cardiovascular control. Although Carassius carassius, the crucian carp, shares this anoxia tolerance, we show that it has a unique ability among vertebrates to retain normal cardiac performance and autonomic cardiovascular regulation for at least 5 days of anoxia. These responses point to an unusual tolerance of a vertebrate heart and autonomic nervous system to prolonged anoxia.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1100763