Emerging clinical applications of RNA

RNA is a versatile biological macromolecule that is crucial in mobilizing and interpreting our genetic information. It is not surprising then that researchers have sought to exploit the inherent properties of RNAs so as to interfere with or repair dysfunctional nucleic acids or proteins and to stimu...

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Bibliographic Details
Published in:Nature (London) 2002-07, Vol.418 (6894), p.252-258
Main Authors: Sullenger, Bruce A, Gilboa, Eli
Format: Article
Language:English
Subjects:
Clinical Trials as Topic
Dendritic Cells - metabolism
Dendritic Cells - transplantation
Gene expression
Gene Expression Regulation
Gene therapy
Genetics
Genetics, Medical - methods
Health aspects
Humanities and Social Sciences
Humans
Immunotherapy - methods
Medical research
multidisciplinary
Mutation - genetics
Nucleic acids
Proteins
review-article
Ribonucleic acid
RNA
RNA - chemistry
RNA - genetics
RNA - metabolism
RNA - therapeutic use
RNA, Catalytic - chemistry
RNA, Catalytic - genetics
RNA, Catalytic - metabolism
RNA, Catalytic - therapeutic use
Science
Science (multidisciplinary)
Trans-Splicing - genetics
Transfection
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Summary:RNA is a versatile biological macromolecule that is crucial in mobilizing and interpreting our genetic information. It is not surprising then that researchers have sought to exploit the inherent properties of RNAs so as to interfere with or repair dysfunctional nucleic acids or proteins and to stimulate the production of therapeutic gene products in a variety of pathological situations. The first generation of the resulting RNA therapeutics are now being evaluated in clinical trials, raising significant interest in this emerging area of medical research.
ISSN:0028-0836
1476-4687
DOI:10.1038/418252a