Mixture toxicity of priority pollutants at no observed effect concentrations (NOECs)

Environmental exposure situations are often characterised by a multitude of heterogeneous chemicals with ambiguous or unknown modes of action present at low concentrations. While multiple exposure is widely acknowledged, arguments are raised that adverse combined effects might not be evoked by mixtu...

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Bibliographic Details
Published in:Ecotoxicology (London) 2002-10, Vol.11 (5), p.299-299
Main Authors: Walter, Helge, Consolaro, Federica, Gramatica, Paola, Scholze, Martin, Altenburger, Rolf
Format: Article
Language:English
Subjects:
Atrazine - toxicity
Biphenyl Compounds - toxicity
Chloral Hydrate - toxicity
Chlorophenols - toxicity
Chlorophyta - drug effects
Chlorophyta - growth & development
Dose-Response Relationship, Drug
Fluorenes - toxicity
Humans
Lindane - toxicity
Naphthalenes - toxicity
Organothiophosphorus Compounds - toxicity
Organotin Compounds - toxicity
Parathion - toxicity
Pollutants
Predictive Value of Tests
Toxicity
Toxicity Tests - standards
Trialkyltin Compounds - toxicity
Water Pollutants, Chemical - administration & dosage
Water Pollutants, Chemical - toxicity
Online Access:Get full text
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Summary:Environmental exposure situations are often characterised by a multitude of heterogeneous chemicals with ambiguous or unknown modes of action present at low concentrations. While multiple exposure is widely acknowledged, arguments are raised that adverse combined effects might not be evoked by mixtures of substances with dissimilar modes of action and being present at only low concentrations. In this study the combined effect of a multiple mixture composed of structurally dissimilar priority pollutants with mostly unknown modes of action has been investigated using an algal biotest. The concentrations of the components in the mixture equalled statistically estimated, individual no observed effect concentrations (NOECs). The observed mixture toxicity was not only clearly higher than expected for any single substance alone, but also well predictable using the concept of independent action.
ISSN:0963-9292
1573-3017
DOI:10.1023/A:1020592802989