Indomethacin prevents impaired perfusion of the dogs's brain after global ischemia

Compression ischemia of the central nervous system (CNS) in heparinized dogs caused areas of diminished cerebral blood flow measured by 14C-antipyrine autoradiography. Intravenous infusion of indomethacin (1.5 or 4.0 mg/kg) approximately 1 hour before ischemia eliminated the circulatory defects. Pro...

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Bibliographic Details
Published in:Stroke (1970) 1978-11, Vol.9 (6), p.591-594
Main Authors: Furlow, Jr, T W, Hallenbeck, J M
Format: Article
Language:English
Subjects:
Animals
Brain Ischemia - physiopathology
Brain Ischemia - prevention & control
Cerebrovascular Circulation - drug effects
Dogs
Indomethacin - pharmacology
Indomethacin - therapeutic use
Male
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Summary:Compression ischemia of the central nervous system (CNS) in heparinized dogs caused areas of diminished cerebral blood flow measured by 14C-antipyrine autoradiography. Intravenous infusion of indomethacin (1.5 or 4.0 mg/kg) approximately 1 hour before ischemia eliminated the circulatory defects. Prophylactic inhibition of prostaglandin synthetase may promote postischemic perfusion of the CNS by preventing vasoconstriction and by anti-hemostatic effects on blood.
ISSN:0039-2499
1524-4628
DOI:10.1161/01.STR.9.6.591