On low-barrier hydrogen bonds and enzyme catalysts--Comment/reply

Warshel et al disagree with conclusions by Cleland and Kreevoy and by Frey et al that "low-barrier hydrogen bonds" can explain enzyme catalysis by supplying up to 20 kcal/mol of energy by "resonance-stabilization." Cleland, Kreevoy and Frey reply.

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1995-07, Vol.269 (5220), p.102-102
Main Authors: Warshel, Arieh, Papazyan, Arno, Kollman, Peter A, Cleland, W W
Format: Article
Language:English
Subjects:
Catalysts
Energy
Environment
Enzymes
Hydrogen
Water
Online Access:Get full text
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Summary:Warshel et al disagree with conclusions by Cleland and Kreevoy and by Frey et al that "low-barrier hydrogen bonds" can explain enzyme catalysis by supplying up to 20 kcal/mol of energy by "resonance-stabilization." Cleland, Kreevoy and Frey reply.
ISSN:0036-8075
1095-9203