Inhibition of Neointimal Smooth Muscle Accumulation After Angioplasty by an Antibody to PDGF

Approximately 30 to 40 percent of atherosclerotic coronary arteries treated by angioplasty or by bypass surgery occlude as a result of restenosis. This restenosis is due principally to the accumulation of neointimal smooth muscle cells, which is also a prominent feature of the advanced lesions of at...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1991-09, Vol.253 (5024), p.1129-1132
Main Authors: Gordon A. A. Ferns, Raines, Elaine W., Sprugel, Katherine H., Motani, Alykhan S., Reidy, Michael A., Ross, Russell
Format: Article
Language:English
Subjects:
Angioplasty
Angioplasty, Balloon - adverse effects
Animals
Antibodies
Antibodies - therapeutic use
Arterial stenosis
Arteries
Arteriosclerosis - etiology
Arteriosclerosis - prevention & control
Balloons
Blood
Cardiovascular disease
Carotid arteries
Carotid Arteries - pathology
Catheters
DNA Replication
Goats - immunology
Humans
Immunoglobulin G - therapeutic use
Lesions
Medical research
Muscle, Smooth, Vascular - pathology
Muscular system
Physical trauma
Physiological aspects
Platelet-derived growth factor
Platelet-Derived Growth Factor - immunology
Platelet-Derived Growth Factor - metabolism
Platelets
Rats
Rats, Nude
Receptors, Cell Surface - metabolism
Receptors, Platelet-Derived Growth Factor
Smooth muscle
Smooth muscle myocytes
Stenosis
Surgery
Viral antibodies
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Summary:Approximately 30 to 40 percent of atherosclerotic coronary arteries treated by angioplasty or by bypass surgery occlude as a result of restenosis. This restenosis is due principally to the accumulation of neointimal smooth muscle cells, which is also a prominent feature of the advanced lesions of atherosclerosis. The factors responsible for the accumulation of intimal smooth muscle cells have not been identified. Platelet-derived growth factor (PDGF) is a potent smooth muscle chemoattractant and mitogen. It is present in platelets and can be formed by endothelium, smooth muscle, and monocyte-derived macrophages. The development of an intimal lesion in the carotid artery of athymic nude rats induced by intraarterial balloon catheter deendothelialization was inhibited by a polyclonal antibody to PDGF. These data demonstrate that endogenous PDGF is involved in the accumulation of neointimal smooth muscle cells associated with balloon injury and may be involved in restenosis after angioplasty, and perhaps in atherogenesis as well.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1653454