Insulin Signaling in Health and Disease

The signaling pathways used by insulin have been identified [M. White, Insulin Signaling Pathway, Sci. STKE (Connections Map, as seen November 2003), http://stke.sciencemag. org/cgi/cm/cmp_12069]. Now our challenge is to understand how the failure of these signals is associated with obesity and the...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2003-12, Vol.302 (5651), p.1710-1711
Main Author: White, Morris F.
Format: Article
Language:English
Subjects:
Anatomy
Animals
Biological and medical sciences
Body Weight
Brain
Causes of
Cytokines - metabolism
Diabetes
Diabetes mellitus
Diabetes Mellitus - etiology
Diabetes Mellitus - metabolism
Diabetes Mellitus, Type 1 - etiology
Diabetes Mellitus, Type 1 - metabolism
Diabetes Mellitus, Type 2 - etiology
Diabetes Mellitus, Type 2 - metabolism
Diabetes. Impaired glucose tolerance
Diseases
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Gene expression regulation
Humans
Individualized Instruction
Inflammation
Insulin
Insulin - metabolism
Insulin Receptor Substrate Proteins
Insulin Resistance
Intracellular Signaling Peptides and Proteins
Islets of Langerhans - metabolism
Medical sciences
Mice
Models, Biological
Narcotics
Neurotransmitters
Obesity
Obesity - etiology
Obesity - metabolism
Pancreas
Phosphoproteins - metabolism
Phosphorylation
Physiological aspects
Proteins
Receptor, Insulin - genetics
Receptor, Insulin - metabolism
Receptors
Signal Transduction
Somatomedins - metabolism
Type 1 diabetes mellitus
Type 2 diabetes mellitus
Viewpoint
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Description
Summary:The signaling pathways used by insulin have been identified [M. White, Insulin Signaling Pathway, Sci. STKE (Connections Map, as seen November 2003), http://stke.sciencemag. org/cgi/cm/cmp_12069]. Now our challenge is to understand how the failure of these signals is associated with obesity and the progressive failure of pancreatic beta cells that leads to diabetes. Whether better management of chronic inflammation can improve insulin action is an important area of investigation. Drugs that stimulate IRS2 (insulin receptor substrate protein 2) synthesis or signaling might be a good starting point. This knowledge will lead to rational strategies that prevent or cure diabetes.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1092952