Neural and Immunological Synaptic Relations

A synapse is a stable adhesive junction between two cells across which information is relayed by directed secretion. The nervous system and immune system utilize these specialized cell surface contacts to directly convey and transduce highly controlled secretory signals between their constituent cel...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2002-10, Vol.298 (5594), p.785-789
Main Authors: Dustin, Michael L., Colman, David R.
Format: Article
Language:English
Subjects:
Anatomy
Animals
Antigen-Presenting Cells - immunology
Antigen-Presenting Cells - physiology
B lymphocytes
Cadherins - physiology
Cell Adhesion
Cell Communication
Cellular biology
Central nervous system
Central Nervous System - physiology
Central Nervous System - ultrastructure
Communication (Thought Transfer)
Daughter cells
Endocytosis
Exocytosis
Immune system
Immunological synapses
Immunology
Information Storage
Integrins - physiology
Lymphocyte Activation
Memory
Molecules
Nervous system
Neurology
Neurons
Neurons - physiology
Neurophysiology
Receptors
Receptors, Antigen, T-Cell - physiology
Synapses
Synapses - physiology
T cell antigen receptors
T lymphocytes
T-Lymphocytes - immunology
T-Lymphocytes - physiology
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Summary:A synapse is a stable adhesive junction between two cells across which information is relayed by directed secretion. The nervous system and immune system utilize these specialized cell surface contacts to directly convey and transduce highly controlled secretory signals between their constituent cell populations. Each of these synaptic types is built around a microdomain structure comprising central active zones of exocytosis and endocytosis encircled by adhesion domains. Surface molecules that may be incorporated into and around the active zones contribute to modulation of the functional state of the synapse.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1076386