On the Origin of Interictal Activity in Human Temporal Lobe Epilepsy in vitro

The origin and mechanisms of human interictal epileptic discharges remain unclear. Here, we describe a spontaneous, rhythmic activity initiated in the subiculum of slices from patients with temporal lobe epilepsy. Synchronous events were similar to interictal discharges of patient electroencephalogr...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2002-11, Vol.298 (5597), p.1418-1421
Main Authors: Cohen, Ivan, Navarro, Vincent, Clemenceau, Stéphane, Baulac, Michel, Miles, Richard
Format: Article
Language:English
Subjects:
Action Potentials
Adult
Biological and medical sciences
Brain
Electroencephalography
Epilepsy
Epilepsy, Temporal Lobe - physiopathology
Excitatory Amino Acid Antagonists - pharmacology
GABA antagonists
gamma-Aminobutyric Acid - metabolism
Glutamic Acid - metabolism
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Hippocampus
Hippocampus - physiopathology
Humans
In Vitro Techniques
Interneurons
Interneurons - physiology
Medical sciences
Membrane potential
Membrane Potentials
Microelectrodes
Middle Aged
Nerve Fibers - physiology
Nervous system (semeiology, syndromes)
Neurology
Neurons
Neurons, Afferent - physiology
Patients
Pyramidal cells
Pyramidal Cells - physiology
Seizures
Signal Transduction
Synaptic Transmission
Temporal lobe
Temporal Lobe - physiopathology
Temporal lobe epilepsy
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Description
Summary:The origin and mechanisms of human interictal epileptic discharges remain unclear. Here, we describe a spontaneous, rhythmic activity initiated in the subiculum of slices from patients with temporal lobe epilepsy. Synchronous events were similar to interictal discharges of patient electroencephalograms. They were suppressed by antagonists of either glutamatergic or γ-aminobutyric acid (GABA)-ergic signaling. The network of neurons discharging during population events comprises both subicular interneurons and a subgroup of pyramidal cells. In these pyramidal cells, GABAergic synaptic events reversed at depolarized potentials. Depolarizing GABAergic responses in neurons downstream to the sclerotic CA1 region contribute to human interictal activity.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1076510