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On the Origin of Interictal Activity in Human Temporal Lobe Epilepsy in vitro
The origin and mechanisms of human interictal epileptic discharges remain unclear. Here, we describe a spontaneous, rhythmic activity initiated in the subiculum of slices from patients with temporal lobe epilepsy. Synchronous events were similar to interictal discharges of patient electroencephalogr...
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Published in: | Science (American Association for the Advancement of Science) 2002-11, Vol.298 (5597), p.1418-1421 |
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creator | Cohen, Ivan Navarro, Vincent Clemenceau, Stéphane Baulac, Michel Miles, Richard |
description | The origin and mechanisms of human interictal epileptic discharges remain unclear. Here, we describe a spontaneous, rhythmic activity initiated in the subiculum of slices from patients with temporal lobe epilepsy. Synchronous events were similar to interictal discharges of patient electroencephalograms. They were suppressed by antagonists of either glutamatergic or γ-aminobutyric acid (GABA)-ergic signaling. The network of neurons discharging during population events comprises both subicular interneurons and a subgroup of pyramidal cells. In these pyramidal cells, GABAergic synaptic events reversed at depolarized potentials. Depolarizing GABAergic responses in neurons downstream to the sclerotic CA1 region contribute to human interictal activity. |
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subjects | Action Potentials Adult Biological and medical sciences Brain Electroencephalography Epilepsy Epilepsy, Temporal Lobe - physiopathology Excitatory Amino Acid Antagonists - pharmacology GABA antagonists gamma-Aminobutyric Acid - metabolism Glutamic Acid - metabolism Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Hippocampus Hippocampus - physiopathology Humans In Vitro Techniques Interneurons Interneurons - physiology Medical sciences Membrane potential Membrane Potentials Microelectrodes Middle Aged Nerve Fibers - physiology Nervous system (semeiology, syndromes) Neurology Neurons Neurons, Afferent - physiology Patients Pyramidal cells Pyramidal Cells - physiology Seizures Signal Transduction Synaptic Transmission Temporal lobe Temporal Lobe - physiopathology Temporal lobe epilepsy |
title | On the Origin of Interictal Activity in Human Temporal Lobe Epilepsy in vitro |
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