New class II-like genes in the murine MHC

Major histocompatibility complex (MHC) class I molecules present endogenous antigens to CD8+ (cytotoxic) T cells. MHC class II molecules present primarily exogenously derived antigens to CD4+ T cells. Three new genes (Ma, Mb1 and Mb2) located between the Pb and Ob genes of the murine MHC have proper...

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Bibliographic Details
Published in:Nature (London) 1991-10, Vol.353 (6344), p.573-576
Main Authors: CHO, S, ATTAYA, M, MONACO, J. J
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Base Sequence
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
genes
Genes, MHC Class II
Genes. Genome
Genetics
Histocompatibility Antigens Class II - genetics
Membrane Proteins - genetics
Mice
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
Proteins
Sequence Alignment
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Summary:Major histocompatibility complex (MHC) class I molecules present endogenous antigens to CD8+ (cytotoxic) T cells. MHC class II molecules present primarily exogenously derived antigens to CD4+ T cells. Three new genes (Ma, Mb1 and Mb2) located between the Pb and Ob genes of the murine MHC have properties indicating that they are members of the MHC class II gene family, but they are the most divergent class II members so far identified and are almost as closely related in sequence to class I genes as they are to the known class II genes.
ISSN:0028-0836
1476-4687
DOI:10.1038/353573a0