Morphine and β-endorphin influence the secretion of the endocrine pancreas

OPIOID PEPTIDES 1–3 are present in high concentrations in those areas of the brain and gastrointestinal tract 4 in which opiate receptors 5 are numerous and a biological response to opiates well established 6 . The report of immunoreactive enkephalin in the pancreas 4 raised the possibility that a s...

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Bibliographic Details
Published in:Nature (London) 1978-11, Vol.276 (5684), p.190-191
Main Authors: IPP, E., DOBBS, R., UNGER, R. H.
Format: Article
Language:English
Subjects:
Animals
Dogs
Endorphins - pharmacology
Glucagon - metabolism
Growth Hormone-Releasing Hormone - metabolism
Humanities and Social Sciences
Insulin - metabolism
Insulin Secretion
Islets of Langerhans - drug effects
Islets of Langerhans - metabolism
letter
Morphine - pharmacology
multidisciplinary
Naloxone - pharmacology
Receptors, Opioid - drug effects
Science
Science (multidisciplinary)
Secretory Rate - drug effects
Time Factors
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Summary:OPIOID PEPTIDES 1–3 are present in high concentrations in those areas of the brain and gastrointestinal tract 4 in which opiate receptors 5 are numerous and a biological response to opiates well established 6 . The report of immunoreactive enkephalin in the pancreas 4 raised the possibility that a similar association between the presence of endogenous peptide and opiate receptors might exist in this organ and would be manifested by a biological response to these agents. We report here that an exogenous opiate and an endogenous opioid peptide both exert biological effects upon the endocrine pancreas that are compatible with the presence of opiate receptors in the islets of Langerhans.
ISSN:0028-0836
1476-4687
DOI:10.1038/276190a0