Loading…
Morphine and β-endorphin influence the secretion of the endocrine pancreas
OPIOID PEPTIDES 1–3 are present in high concentrations in those areas of the brain and gastrointestinal tract 4 in which opiate receptors 5 are numerous and a biological response to opiates well established 6 . The report of immunoreactive enkephalin in the pancreas 4 raised the possibility that a s...
Saved in:
| Published in: | Nature (London) 1978-11, Vol.276 (5684), p.190-191 |
|---|---|
| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c340t-34b8b1b77def6e68a371c24183bd98212d18a5dac9b2a16d41bc820a971c10e53 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c340t-34b8b1b77def6e68a371c24183bd98212d18a5dac9b2a16d41bc820a971c10e53 |
| container_end_page | 191 |
| container_issue | 5684 |
| container_start_page | 190 |
| container_title | Nature (London) |
| container_volume | 276 |
| creator | IPP, E. DOBBS, R. UNGER, R. H. |
| description | OPIOID PEPTIDES
1–3
are present in high concentrations in those areas of the brain and gastrointestinal tract
4
in which opiate receptors
5
are numerous and a biological response to opiates well established
6
. The report of immunoreactive enkephalin in the pancreas
4
raised the possibility that a similar association between the presence of endogenous peptide and opiate receptors might exist in this organ and would be manifested by a biological response to these agents. We report here that an exogenous opiate and an endogenous opioid peptide both exert biological effects upon the endocrine pancreas that are compatible with the presence of opiate receptors in the islets of Langerhans. |
| doi_str_mv | 10.1038/276190a0 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_74335854</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>74335854</sourcerecordid><originalsourceid>FETCH-LOGICAL-c340t-34b8b1b77def6e68a371c24183bd98212d18a5dac9b2a16d41bc820a971c10e53</originalsourceid><addsrcrecordid>eNplkLtOxDAQRS3Ea1mQ-ACKVAiKgMd2bKdEK15iEQ3UkWNP2KyyzmInBb_Fh_BNZAnQUI0058yV5hJyDPQCKNeXTEnIqaFbZAJCyVRIrbbJhFKmU6q53CcHMS4ppRkosUd2GcicwYQ8PLZhvag9Jsa75PMjRe_GTVL7qunRW0y6BSYRbcCubn3SVt-LjWjD5nJt_MBMPCQ7lWkiHv3MKXm5uX6e3aXzp9v72dU8tVzQLuWi1CWUSjmsJEptuALLBGheulwzYA60yZyxeckMSCegtJpRkw8aUMz4lJyOuevQvvUYu2JVR4tNYzy2fSyU4DzTmRjEs1G0oY0xYFWsQ70y4b0AWmxqK35rG9STn8y-XKH7E8eeBnw-4jgA_4qhWLZ98MOX_6O-AO7CdNY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>74335854</pqid></control><display><type>article</type><title>Morphine and β-endorphin influence the secretion of the endocrine pancreas</title><source>Springer Nature - Connect here FIRST to enable access</source><creator>IPP, E. ; DOBBS, R. ; UNGER, R. H.</creator><creatorcontrib>IPP, E. ; DOBBS, R. ; UNGER, R. H.</creatorcontrib><description>OPIOID PEPTIDES
1–3
are present in high concentrations in those areas of the brain and gastrointestinal tract
4
in which opiate receptors
5
are numerous and a biological response to opiates well established
6
. The report of immunoreactive enkephalin in the pancreas
4
raised the possibility that a similar association between the presence of endogenous peptide and opiate receptors might exist in this organ and would be manifested by a biological response to these agents. We report here that an exogenous opiate and an endogenous opioid peptide both exert biological effects upon the endocrine pancreas that are compatible with the presence of opiate receptors in the islets of Langerhans.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/276190a0</identifier><identifier>PMID: 216921</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Dogs ; Endorphins - pharmacology ; Glucagon - metabolism ; Growth Hormone-Releasing Hormone - metabolism ; Humanities and Social Sciences ; Insulin - metabolism ; Insulin Secretion ; Islets of Langerhans - drug effects ; Islets of Langerhans - metabolism ; letter ; Morphine - pharmacology ; multidisciplinary ; Naloxone - pharmacology ; Receptors, Opioid - drug effects ; Science ; Science (multidisciplinary) ; Secretory Rate - drug effects ; Time Factors</subject><ispartof>Nature (London), 1978-11, Vol.276 (5684), p.190-191</ispartof><rights>Springer Nature Limited 1978</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c340t-34b8b1b77def6e68a371c24183bd98212d18a5dac9b2a16d41bc820a971c10e53</citedby><cites>FETCH-LOGICAL-c340t-34b8b1b77def6e68a371c24183bd98212d18a5dac9b2a16d41bc820a971c10e53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/216921$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>IPP, E.</creatorcontrib><creatorcontrib>DOBBS, R.</creatorcontrib><creatorcontrib>UNGER, R. H.</creatorcontrib><title>Morphine and β-endorphin influence the secretion of the endocrine pancreas</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>OPIOID PEPTIDES
1–3
are present in high concentrations in those areas of the brain and gastrointestinal tract
4
in which opiate receptors
5
are numerous and a biological response to opiates well established
6
. The report of immunoreactive enkephalin in the pancreas
4
raised the possibility that a similar association between the presence of endogenous peptide and opiate receptors might exist in this organ and would be manifested by a biological response to these agents. We report here that an exogenous opiate and an endogenous opioid peptide both exert biological effects upon the endocrine pancreas that are compatible with the presence of opiate receptors in the islets of Langerhans.</description><subject>Animals</subject><subject>Dogs</subject><subject>Endorphins - pharmacology</subject><subject>Glucagon - metabolism</subject><subject>Growth Hormone-Releasing Hormone - metabolism</subject><subject>Humanities and Social Sciences</subject><subject>Insulin - metabolism</subject><subject>Insulin Secretion</subject><subject>Islets of Langerhans - drug effects</subject><subject>Islets of Langerhans - metabolism</subject><subject>letter</subject><subject>Morphine - pharmacology</subject><subject>multidisciplinary</subject><subject>Naloxone - pharmacology</subject><subject>Receptors, Opioid - drug effects</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Secretory Rate - drug effects</subject><subject>Time Factors</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><recordid>eNplkLtOxDAQRS3Ea1mQ-ACKVAiKgMd2bKdEK15iEQ3UkWNP2KyyzmInBb_Fh_BNZAnQUI0058yV5hJyDPQCKNeXTEnIqaFbZAJCyVRIrbbJhFKmU6q53CcHMS4ppRkosUd2GcicwYQ8PLZhvag9Jsa75PMjRe_GTVL7qunRW0y6BSYRbcCubn3SVt-LjWjD5nJt_MBMPCQ7lWkiHv3MKXm5uX6e3aXzp9v72dU8tVzQLuWi1CWUSjmsJEptuALLBGheulwzYA60yZyxeckMSCegtJpRkw8aUMz4lJyOuevQvvUYu2JVR4tNYzy2fSyU4DzTmRjEs1G0oY0xYFWsQ70y4b0AWmxqK35rG9STn8y-XKH7E8eeBnw-4jgA_4qhWLZ98MOX_6O-AO7CdNY</recordid><startdate>19781109</startdate><enddate>19781109</enddate><creator>IPP, E.</creator><creator>DOBBS, R.</creator><creator>UNGER, R. H.</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19781109</creationdate><title>Morphine and β-endorphin influence the secretion of the endocrine pancreas</title><author>IPP, E. ; DOBBS, R. ; UNGER, R. H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c340t-34b8b1b77def6e68a371c24183bd98212d18a5dac9b2a16d41bc820a971c10e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Animals</topic><topic>Dogs</topic><topic>Endorphins - pharmacology</topic><topic>Glucagon - metabolism</topic><topic>Growth Hormone-Releasing Hormone - metabolism</topic><topic>Humanities and Social Sciences</topic><topic>Insulin - metabolism</topic><topic>Insulin Secretion</topic><topic>Islets of Langerhans - drug effects</topic><topic>Islets of Langerhans - metabolism</topic><topic>letter</topic><topic>Morphine - pharmacology</topic><topic>multidisciplinary</topic><topic>Naloxone - pharmacology</topic><topic>Receptors, Opioid - drug effects</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Secretory Rate - drug effects</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>IPP, E.</creatorcontrib><creatorcontrib>DOBBS, R.</creatorcontrib><creatorcontrib>UNGER, R. H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>IPP, E.</au><au>DOBBS, R.</au><au>UNGER, R. H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Morphine and β-endorphin influence the secretion of the endocrine pancreas</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1978-11-09</date><risdate>1978</risdate><volume>276</volume><issue>5684</issue><spage>190</spage><epage>191</epage><pages>190-191</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>OPIOID PEPTIDES
1–3
are present in high concentrations in those areas of the brain and gastrointestinal tract
4
in which opiate receptors
5
are numerous and a biological response to opiates well established
6
. The report of immunoreactive enkephalin in the pancreas
4
raised the possibility that a similar association between the presence of endogenous peptide and opiate receptors might exist in this organ and would be manifested by a biological response to these agents. We report here that an exogenous opiate and an endogenous opioid peptide both exert biological effects upon the endocrine pancreas that are compatible with the presence of opiate receptors in the islets of Langerhans.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>216921</pmid><doi>10.1038/276190a0</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1978-11, Vol.276 (5684), p.190-191 |
| issn | 0028-0836 1476-4687 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74335854 |
| source | Springer Nature - Connect here FIRST to enable access |
| subjects | Animals Dogs Endorphins - pharmacology Glucagon - metabolism Growth Hormone-Releasing Hormone - metabolism Humanities and Social Sciences Insulin - metabolism Insulin Secretion Islets of Langerhans - drug effects Islets of Langerhans - metabolism letter Morphine - pharmacology multidisciplinary Naloxone - pharmacology Receptors, Opioid - drug effects Science Science (multidisciplinary) Secretory Rate - drug effects Time Factors |
| title | Morphine and β-endorphin influence the secretion of the endocrine pancreas |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T18%3A37%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Morphine%20and%20%CE%B2-endorphin%20influence%20the%20secretion%20of%20the%20endocrine%20pancreas&rft.jtitle=Nature%20(London)&rft.au=IPP,%20E.&rft.date=1978-11-09&rft.volume=276&rft.issue=5684&rft.spage=190&rft.epage=191&rft.pages=190-191&rft.issn=0028-0836&rft.eissn=1476-4687&rft_id=info:doi/10.1038/276190a0&rft_dat=%3Cproquest_cross%3E74335854%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c340t-34b8b1b77def6e68a371c24183bd98212d18a5dac9b2a16d41bc820a971c10e53%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=74335854&rft_id=info:pmid/216921&rfr_iscdi=true |