Anterior-Posterior Guidance of Commissural Axons by Wnt-Frizzled Signaling

Commissural neurons in the mammalian dorsal spinal cord send axons ventrally toward the floor plate, where they cross the midline and turn anteriorly toward the brain; a gradient of chemoattractant(s) inside the spinal cord controls this turning. In rodents, several Wnt proteins stimulate the extens...

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Published in:Science (American Association for the Advancement of Science) 2003-12, Vol.302 (5652), p.1984-1988
Main Authors: Lyuksyutova, Anna I., Lu, Chin-Chun, Milanesio, Nancy, King, Leslie A., Guo, Nini, Wang, Yanshu, Nathans, Jeremy, Tessier-Lavigne, Marc, Zou, Yimin
Format: Article
Language:English
Subjects:
Animals
Axons
Axons - physiology
Axons - ultrastructure
Biological and medical sciences
Brain - embryology
Brain - metabolism
Central Nervous System - cytology
Central Nervous System - embryology
Central Nervous System - metabolism
Collagens
COS Cells
Cues
Culture Techniques
Diffusion
Embryos
Frizzled Receptors
Frizzled3 protein
Fundamental and applied biological sciences. Psychology
Gels
Gene Expression Profiling
Growth cones
Growth Cones - physiology
Growth Cones - ultrastructure
Guidance
House mouse
In Situ Hybridization
Membrane Proteins
Mice
Mice as laboratory animals
Mice, Knockout
Nervous system
Neurology
Neurons
Neurons - physiology
Neuroscience
Neurotransmitters
Population Distribution
Proteins - pharmacology
Proto-Oncogene Proteins - metabolism
Quantification
Rats
Rats, Sprague-Dawley
Receptors, G-Protein-Coupled - genetics
Receptors, G-Protein-Coupled - metabolism
Signal Transduction
Signaling
Signals and signaling
Spinal cord
Spinal Cord - cytology
Spinal Cord - embryology
Spinal Cord - metabolism
Stimuli
Transfection
Vertebrates: nervous system and sense organs
Wnt Proteins
Wnt4 gene
Wnt4 Protein
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cited_by cdi_FETCH-LOGICAL-c782t-c5025ef46166d7ed21dd8de02e4745dfd0b7e784e66b14dd261f470f911017763
cites cdi_FETCH-LOGICAL-c782t-c5025ef46166d7ed21dd8de02e4745dfd0b7e784e66b14dd261f470f911017763
container_end_page 1988
container_issue 5652
container_start_page 1984
container_title Science (American Association for the Advancement of Science)
container_volume 302
creator Lyuksyutova, Anna I.
Lu, Chin-Chun
Milanesio, Nancy
King, Leslie A.
Guo, Nini
Wang, Yanshu
Nathans, Jeremy
Tessier-Lavigne, Marc
Zou, Yimin
description Commissural neurons in the mammalian dorsal spinal cord send axons ventrally toward the floor plate, where they cross the midline and turn anteriorly toward the brain; a gradient of chemoattractant(s) inside the spinal cord controls this turning. In rodents, several Wnt proteins stimulate the extension of commissural axons after midline crossing (postcrossing). We found that Wnt4 messenger RNA is expressed in a decreasing anterior-to-posterior gradient in the floor plate, and that a directed source of Wnt4 protein attracted postcrossing commissural axons. Commissural axons in mice lacking the Wnt receptor Frizzled3 displayed anterior-posterior guidance defects after midline crossing. Thus, Wnt-Frizzled signaling guides commissural axons along the anterior-posterior axis of the spinal cord.
doi_str_mv 10.1126/science.1089610
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a gradient of chemoattractant(s) inside the spinal cord controls this turning. In rodents, several Wnt proteins stimulate the extension of commissural axons after midline crossing (postcrossing). We found that Wnt4 messenger RNA is expressed in a decreasing anterior-to-posterior gradient in the floor plate, and that a directed source of Wnt4 protein attracted postcrossing commissural axons. Commissural axons in mice lacking the Wnt receptor Frizzled3 displayed anterior-posterior guidance defects after midline crossing. Thus, Wnt-Frizzled signaling guides commissural axons along the anterior-posterior axis of the spinal cord.</abstract><cop>Washington, DC</cop><pub>American Association for the Advancement of Science</pub><pmid>14671310</pmid><doi>10.1126/science.1089610</doi><tpages>5</tpages></addata></record>
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identifier ISSN: 0036-8075
ispartof Science (American Association for the Advancement of Science), 2003-12, Vol.302 (5652), p.1984-1988
issn 0036-8075
1095-9203
language eng
recordid cdi_proquest_miscellaneous_743359634
source American Association for the Advancement of Science; Education Collection (Proquest) (PQ_SDU_P3); Social Science Premium Collection (Proquest) (PQ_SDU_P3); Alma/SFX Local Collection
subjects Animals
Axons
Axons - physiology
Axons - ultrastructure
Biological and medical sciences
Brain - embryology
Brain - metabolism
Central Nervous System - cytology
Central Nervous System - embryology
Central Nervous System - metabolism
Collagens
COS Cells
Cues
Culture Techniques
Diffusion
Embryos
Frizzled Receptors
Frizzled3 protein
Fundamental and applied biological sciences. Psychology
Gels
Gene Expression Profiling
Growth cones
Growth Cones - physiology
Growth Cones - ultrastructure
Guidance
House mouse
In Situ Hybridization
Membrane Proteins
Mice
Mice as laboratory animals
Mice, Knockout
Nervous system
Neurology
Neurons
Neurons - physiology
Neuroscience
Neurotransmitters
Population Distribution
Proteins - pharmacology
Proto-Oncogene Proteins - metabolism
Quantification
Rats
Rats, Sprague-Dawley
Receptors, G-Protein-Coupled - genetics
Receptors, G-Protein-Coupled - metabolism
Signal Transduction
Signaling
Signals and signaling
Spinal cord
Spinal Cord - cytology
Spinal Cord - embryology
Spinal Cord - metabolism
Stimuli
Transfection
Vertebrates: nervous system and sense organs
Wnt Proteins
Wnt4 gene
Wnt4 Protein
title Anterior-Posterior Guidance of Commissural Axons by Wnt-Frizzled Signaling
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